| Dose-response effects of 32P radioactive stents in an atherosclerotic porcine coronary model. | |
| | |
MedLine Citation:
|
PMID: 10510059 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Experimental studies have demonstrated that 32P radioactive stents reduce neointimal formation at 28 days in porcine iliac and coronary arteries. Our objective was to determine the long-term dose-response effects of 1.0- to 12.0-microCi 32P radioactive stents in a porcine atherosclerotic coronary model. METHODS AND RESULTS: Control (n=19) and 1.0- to 12.0-microCi 32P radioactive (n=43) stents (total, n=62) were implanted in the coronary arteries of 31 miniature swine at 28 days after creation of a fibrocellular plaque by overstretch balloon injury and cholesterol feeding. Angiography and histomorphometry were performed at 6 months. Stent thrombosis occurred in 3 radioactive (7.7%) and no control stents (P=0.54). On histology, the mean neointimal area and the percent in-stent stenosis correlated positively with increasing stent activity (r=0.64, P<0.001). The mean neointimal area (mm2) for the stents with >/=3.0 microCi 32P (3.57+/-1.21) was significantly greater than that for the nonradioactive stents (1.78+/-0.68, P<0.0001). The neointima of the stents with >/=3.0 microCi 32P was composed of smooth muscle cells, matrix proteoglycans, calcification, foam cells, and cholesterol clefts. CONCLUSIONS: Continuous low-dose-rate irradiation delivered by high-activity (32)P radioactive stents promotes the formation of an "atheromatous" neointima after 6 months in this experimental model. These data may be useful for predicting late tissue responses to radioactive stents in human coronary arteries. |
| | |
Authors:
|
A J Carter; D Scott; L Bailey; T Hoopes; R Jones; R Virmani |
Related Documents
:
|
15868799 - Changes in the mechanical environment of stenotic arteries during interaction with sten... 10567319 - Stent-supported reconstruction of the aortoiliac bifurcation with the kissing balloon t... 8813449 - Local methylprednisolone inhibition of foreign body response to coated intracoronary st... 20920839 - Endovascular treatment of acute limb ischemia secondary to fracture of a popliteal arte... 16275459 - Surgical management of acute carotid thrombosis after carotid stenting: a report of thr... 19935599 - Caval migration of a ureteral j-stent after simultaneous ureter and iliac vein perforat... 3336969 - Rotational atherectomy in atherosclerotic rabbit iliac arteries. 15868799 - Changes in the mechanical environment of stenotic arteries during interaction with sten... 23515739 - Endovascular correction of abdominal aortic aneurysm as a late complication of type a a... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Circulation Volume: 100 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 1999 Oct |
Date Detail:
|
Created Date: 1999-10-21 Completed Date: 1999-10-21 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1548-54 Citation Subset: AIM; IM |
Affiliation:
|
Cardiology Research Foundation, Washington Hospital Center, Walter Reed Army Medical Center, Washington, DC 20100, USA. ajc2@mhg.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Coronary Angiography Coronary Artery Disease / therapy* Coronary Thrombosis / etiology Coronary Vessels / pathology, radiation effects* Dose-Response Relationship, Radiation Muscle, Smooth, Vascular / pathology, radiography* Phosphorus Radioisotopes / therapeutic use* Stents* / adverse effects Swine Swine, Miniature |
| Chemical | |
Reg. No./Substance:
|
0/Phosphorus Radioisotopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Acute right ventricular restrictive physiology after repair of tetralogy of Fallot: association with...
Next Document: Regulation of shear stress in the canine coronary microcirculation.