Document Detail


Dose-response effect of ferulic acid against nicotine-induced tissue damage and altered lipid levels in experimental rats: a pathohistological evaluation.
MedLine Citation:
PMID:  18844727     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the present study, ferulic acid (FA), a naturally occurring nutritional compound, was investigated for its protective effect against nicotine-induced toxicity in a dose dependent manner. The toxicity was induced by subcutaneous injection of nicotine at a dose of 2.5 mg/kg body weight (b.w.) for 22 weeks in female albino Wister rats. Simultaneously, rats were treated with FA at three different doses (10, 20 and 40 mg/kg b.w.) via intragastric intubations for 22 weeks. At the end of the experiment, circulatory marker enzymes (i.e. lactate dehydrogenase and alkaline phosphatase) and tissue (lung, liver and kidney) lipid levels (i.e. cholesterol, free fatty acids, triglycerides and phospholipids) were analysed, which were significantly increased in the nicotine-treated group, whereas FA treatment positively modulated these levels. FA at a dose of 20 mg/kg b.w. was found to be more effective when compared with the other two doses. The lung, liver and kidney excised from the different groups were fixed and stained to perform histological assessments. The protective effect of FA on histological observations confirms that 20 mg/kg b.w. of FA modulates the deleterious effects of nicotine. The results suggest that FA exerts its inhibitory action against nicotine-induced tissue damage through its antioxidant and antihyperlipidemic properties.
Authors:
Ram Sudheer Adluri; Devipriya Nagarajan; Vishwanathan Periyaswamy; Padmanabhan Menon Venugopal
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Fundamental & clinical pharmacology     Volume:  22     ISSN:  1472-8206     ISO Abbreviation:  Fundam Clin Pharmacol     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-10     Completed Date:  2009-05-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710411     Medline TA:  Fundam Clin Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  557-67     Citation Subset:  IM    
Affiliation:
Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamil Nadu, India.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antilipemic Agents / administration & dosage*
Antioxidants / administration & dosage
Coumaric Acids / administration & dosage*
Dose-Response Relationship, Drug
Female
Kidney / drug effects,  metabolism,  pathology
Lipid Peroxidation / drug effects,  physiology
Lipids / blood*
Liver / drug effects,  metabolism,  pathology
Lung / drug effects,  metabolism,  pathology
Nicotine / antagonists & inhibitors*,  toxicity*
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
0/Antilipemic Agents; 0/Antioxidants; 0/Coumaric Acids; 0/Lipids; 1135-24-6/ferulic acid; 54-11-5/Nicotine

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