Document Detail

Dose-response and coagulation and hemostatic factors.
MedLine Citation:
PMID:  11427778     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The purpose of this study was to evaluate the dose-response relations of regular physical activity on platelet function, blood coagulation factors, and fibrinolytic factors, on the basis of studies with appropriate experimental design. METHODS: MEDLINE-based literature search supplemented with relevant review articles and other individual articles was used. The review concentrates on controlled randomized clinical trials on the impact of regular physical exercise on platelet function, and on blood coagulation and fibrinolytic factors. RESULTS: Physical exercise acutely activates platelets and the fibrinolytic system, and some factors of the blood coagulation cascade. These findings, the earliest of which were published already in the 1960s, are mainly derived from uncontrolled observations. These studies have led to the conclusion that unbalanced activation of the hemostatic system during acute exercise may be part of the mechanisms for sudden cardiac events during or shortly after heavy physical exercise. The effects of regular physical exercise on various aspects of platelet function, blood coagulation, and fibrinolysis have been the object in only a few controlled randomized trials. With the exception of data on platelet function, the results remain contradictory. CONCLUSION: Controlled randomized clinical trials with adequate statistical power and experimental study designs with subjects of different ages and health status are warranted for the evaluation of the dose-response issues to clearly delineate the preventive and therapeutic potential of regular physical exercise.
R Rauramaa; G Li; S B Väisänen
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  33     ISSN:  0195-9131     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-06-27     Completed Date:  2001-08-02     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S516-20; discussion S528-9     Citation Subset:  IM; S    
Kuopio Research Institute of Exercise Medicine, University of Kuopio, Finland.
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MeSH Terms
Blood Coagulation*
Blood Platelets / physiology*
Middle Aged
Physical Fitness
Platelet Function Tests
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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