| Dose-ranging studies of clofilium, an antiarrhythmic quaternary ammonium. | |
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MedLine Citation:
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PMID: 6692647 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Clofilium, a new quaternary ammonium antiarrhythmic without apparent ganglion-blocking effect, was evaluated in 25 patients, 22 with a history of ventricular arrhythmias and three with paroxysmal supraventricular arrhythmias. The study, including programmed atrial and ventricular stimulation, was carried out before and after infusion of 20 to 240 micrograms/kg IV as a single dose. Continuous Holter monitoring was carried out the day before the study through the fourth day after study, and laboratory parameters were monitored for up to 2 wk. There were no changes in intra-atrial and intraventricular conduction times or in AH or HV intervals. There were increases in QT interval, atrial effective refractory period, and ventricular refractory period. The atrioventricular nodal effective refractory period was unchanged. No side effects were noted, nor were changes in blood pressure or laboratory parameters. Monitoring revealed no change in frequency of premature ventricular complexes between the 24 hr before drug infusion and the 96 hr thereafter. In one patient refractoriness of the His-Purkinje system was increased and in two patients atrial fibrillation converted to sinus rhythm after clofilium. Three patients had sustained ventricular tachycardia with programmed stimulation before clofilium infusion; none had more than three repetitive ventricular responses after it. Clofilium increases atrial and ventricular effective refractory period without changing conduction time and, despite no apparent change in premature ventricular complex frequency, it can abolish the ability to induce ventricular tachycardia by programmed stimulation and is also well tolerated. |
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Authors:
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E V Platia; P R Reid |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Clinical pharmacology and therapeutics Volume: 35 ISSN: 0009-9236 ISO Abbreviation: Clin. Pharmacol. Ther. Publication Date: 1984 Feb |
Date Detail:
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Created Date: 1984-03-12 Completed Date: 1984-03-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372741 Medline TA: Clin Pharmacol Ther Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 193-202 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Arrhythmias, Cardiac / drug therapy* Dose-Response Relationship, Drug Drug Evaluation Electrophysiology Female Humans Infusions, Parenteral Male Middle Aged Quaternary Ammonium Compounds / therapeutic use* |
| Grant Support | |
ID/Acronym/Agency:
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5M01RR35-20/RR/NCRR NIH HHS; RR00035-21/RR/NCRR NIH HHS; RR00722-9/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Quaternary Ammonium Compounds; 68379-02-2/clofilium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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