| Dose issues in antiepileptic therapy. | |
| | |
MedLine Citation:
|
PMID: 22959449 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Antiepileptic drug (AED) therapy is complex, with numerous traditional drugs and more than 10 second-generation drugs being approved since the mid-1990s. The burden of epilepsy is compounded by the adverse effects of these drugs, which comprise a variety of manifestations, the most devastating of which is their association with physical and cognitive foetal malformations in babies exposed to these agents in utero. Many effects are dose-related - a clear understanding of these adverse effects is desirable to be able to adjust medications and medication regimens to suit individual patient needs and to try to prevent them, by a careful introduction, slow escalation, well-considered combination and possible pre-exposure testing of patients for their tolerance, to each proposed AED. The overall problem and the profiles of the main agents are outlined from the perspective of dose-related issues. |
| | |
Authors:
|
F Vajda |
Related Documents
:
|
9339409 - Anesthetic implications of epilepsy, status epilepticus, and epilepsy surgery. 23033229 - Thrombotic events associated with c1 esterase inhibitor products in patients with hered... 3621099 - Oral phenobarbital loading: a safe method of barbiturate and nonbarbiturate hypnosedati... 12151119 - New strategies for the identification of drugs to prevent the development or progressio... 9100249 - New drugs and vagal stimulation for treatment of epilepsy--the israeli experience. 10030429 - Valproate in the treatment of epilepsy in people with intellectual disability. 8983129 - Integrated control of tropical animal parasitoses. 1107969 - Antiserotonin agents in the treatment of migraine. 20615199 - Influence of hplc retention data and molecular modeling descriptors on prediction of ph... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-9-4 |
Journal Detail:
|
Title: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia Volume: - ISSN: 1532-2653 ISO Abbreviation: J Clin Neurosci Publication Date: 2012 Sep |
Date Detail:
|
Created Date: 2012-9-10 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9433352 Medline TA: J Clin Neurosci Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Department of Medicine and Neurosciences, Royal Melbourne Hospital and University of Melbourne, P.O. Box 2116, Parkville, Victoria 3050, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 1: Clinical, ...
Next Document: Effects of resveratrol on growth and function of rat ovarian granulosa cells.