Document Detail

Dose of human menopausal gonadotropin influences the outcome of an in vitro fertilization program.
MedLine Citation:
PMID:  3119377     Owner:  NLM     Status:  MEDLINE    
This study compares outcomes of in vitro fertilization (IVF) in two groups of 57 patients when either 2 (group 1) or 3 (group 2) ampules of human menopausal gonadotropin (hMG) were administered daily. Treatment began on day 3 of the cycle and was discontinued when at least 2 follicles attained diameters greater than or equal to 1.5 cm. Human chorionic gonadotropin (hCG) was given either 24 or 48 hours after the last dose of hMG. Although serum estradiol levels were lower in group 1, the average number of oocytes retrieved (3.2 versus 2.9), fertilized (1.9 versus 2.0), and cleaved (1.7 versus 1.8) per completed cycle did not differ between groups 1 and 2. Likewise, the number of oocytes that fertilized abnormally was similar in both groups (0.5 versus 0.3/cycle). However, the number of atretic oocytes (0.03 versus 0.5/cycle) and the percent of oocytes recovered from the cul-de-sac (0 versus 7.2%) were significantly (P less than 0.05) lower in group 1. In group 1, administration of hCG 48 hours after the last dose of hMG was associated with a higher number of cleaving embryos (2.1 versus 1.5/cycle) and a higher pregnancy rate (34.8 versus 14.7%; P less than 0.05) when compared with injection at 24 hours. In group 2, the interval between hMG and hCG did not influence these results. Together, the associations between fewer oocytes that were atretic or recovered from the cul-de-sac, and a trend toward a higher pregnancy rate, suggest that follicular recruitment with 2 ampules of hMG is more appropriate than 3 ampules in an IVF program.
Z Ben-Rafael; C A Benadiva; M Ausmanas; B Barber; L Blasco; G L Flickinger; L Mastroianni
Related Documents :
16274607 - Live birth after ivf in a 46-year-old woman.
16769057 - Multinucleation and cleavage of embryos derived from in vitro-matured oocytes.
9531897 - Pregnancy after human donor oocyte cryopreservation and thawing in association with int...
11172857 - Successful pregnancy and delivery from frozen-thawed embryos after intracytoplasmic spe...
9792997 - Type i and type iii procollagen propeptides in amniotic fluid of normal pregnancies and...
11032207 - Lifetime patterns of contraception and their relationship to unintended pregnancies.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Fertility and sterility     Volume:  48     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1988-01-15     Completed Date:  1988-01-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  964-8     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Sackler School of Medicine, Tel-Aviv University, Israel.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Chorionic Gonadotropin / therapeutic use
Estradiol / blood
Fertilization in Vitro*
Infertility / therapy
Menotropins / administration & dosage*
Ovarian Follicle / drug effects
Ovulation Induction
Retrospective Studies
Grant Support
F5-WI5060//PHS HHS
Reg. No./Substance:
0/Chorionic Gonadotropin; 50-28-2/Estradiol; 61489-71-2/Menotropins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The effect of the dose of human chorionic gonadotropin and the type of gonadotropin stimulation on o...
Next Document:  In vitro fertilization and embryo transfer: treatment-dependent versus -independent pregnancies.