Document Detail


Dose of human menopausal gonadotropin influences the outcome of an in vitro fertilization program.
MedLine Citation:
PMID:  3119377     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study compares outcomes of in vitro fertilization (IVF) in two groups of 57 patients when either 2 (group 1) or 3 (group 2) ampules of human menopausal gonadotropin (hMG) were administered daily. Treatment began on day 3 of the cycle and was discontinued when at least 2 follicles attained diameters greater than or equal to 1.5 cm. Human chorionic gonadotropin (hCG) was given either 24 or 48 hours after the last dose of hMG. Although serum estradiol levels were lower in group 1, the average number of oocytes retrieved (3.2 versus 2.9), fertilized (1.9 versus 2.0), and cleaved (1.7 versus 1.8) per completed cycle did not differ between groups 1 and 2. Likewise, the number of oocytes that fertilized abnormally was similar in both groups (0.5 versus 0.3/cycle). However, the number of atretic oocytes (0.03 versus 0.5/cycle) and the percent of oocytes recovered from the cul-de-sac (0 versus 7.2%) were significantly (P less than 0.05) lower in group 1. In group 1, administration of hCG 48 hours after the last dose of hMG was associated with a higher number of cleaving embryos (2.1 versus 1.5/cycle) and a higher pregnancy rate (34.8 versus 14.7%; P less than 0.05) when compared with injection at 24 hours. In group 2, the interval between hMG and hCG did not influence these results. Together, the associations between fewer oocytes that were atretic or recovered from the cul-de-sac, and a trend toward a higher pregnancy rate, suggest that follicular recruitment with 2 ampules of hMG is more appropriate than 3 ampules in an IVF program.
Authors:
Z Ben-Rafael; C A Benadiva; M Ausmanas; B Barber; L Blasco; G L Flickinger; L Mastroianni
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Fertility and sterility     Volume:  48     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1988-01-15     Completed Date:  1988-01-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  964-8     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Sackler School of Medicine, Tel-Aviv University, Israel.
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MeSH Terms
Descriptor/Qualifier:
Chorionic Gonadotropin / therapeutic use
Estradiol / blood
Female
Fertilization in Vitro*
Humans
Infertility / therapy
Menotropins / administration & dosage*
Oocytes
Ovarian Follicle / drug effects
Ovulation Induction
Pregnancy
Retrospective Studies
Grant Support
ID/Acronym/Agency:
F5-WI5060//PHS HHS
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin; 50-28-2/Estradiol; 61489-71-2/Menotropins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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