Document Detail


Dose effects of modified alternate-day fasting regimens on in vivo cell proliferation and plasma insulin-like growth factor-1 in mice.
MedLine Citation:
PMID:  17495119     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Reduced cell proliferation is associated with lower cancer risk. Alternate-day fasting (ADF), defined as alternating 24-h periods of ad libitum feeding and fasting, decreases cell proliferation. The effect of modified regimens of ADF on cell proliferation, however, has not been examined. This study measured the effects of modified ADF regimens on prostate and splenic T-cell proliferation and circulating insulin-like growth factor-1 (IGF-1) levels in mice. In a 4-wk study, 24 male C57BL/6J mice were randomized to one of four interventions: 1) ADF-25% [25% calorie restriction (CR) on fast day], 2) ADF-50% (50% CR on fast day), 3) ADF-100% (100% CR on fast day), and 4) control. Body weight of the ADF-100% group was less (P < 0.005) than that of the ADF-25% and ADF-50% groups posttreatment. On the feast day, the ADF-100% and ADF-50% groups ate 85% and 45% more food, respectively, than controls, indicating a hyperphagic response to fasting. Proliferation rates of T-cells were 6% and 30% lower (P < 0.05) in the ADF-50% and ADF-100% groups, respectively, relative to controls. Prostate cell proliferation was reduced (P < 0.05) by 49% in the ADF-100% group, relative to controls, but did not change in the other groups. IGF-1 levels were reduced (P < 0.05) by 40%, relative to controls, in the ADF-100% group. These findings confirm the beneficial effects of ADF-100% on cancer risk by decreasing cell proliferation and IGF-1 levels and suggest that modified ADF regimens comprising 25-50% CR on the fast day do not replicate these effects.
Authors:
Krista A Varady; D J Roohk; Marc K Hellerstein
Related Documents :
20193259 - Rapamycin enhances the susceptibility of both androgen-dependent and -independent prost...
10822009 - Estrogen and aryl hydrocarbon receptor expression and crosstalk in human ishikawa endom...
7556169 - Intracellular levels and secretion of insulin-like-growth-factor-binding proteins in mc...
2638149 - Induction of 2'-5' oligoadenylate synthetase and activation of ribonuclease in tamoxife...
14518029 - Molecular characterization of human prostate carcinoma cell lines.
10799339 - Cadmium induces c-myc, p53, and c-jun expression in normal human prostate epithelial ce...
3342809 - Morphological and immunohistochemical characteristics of a cell line originated from no...
18768219 - Engineered extracellular matrices with cleavable crosslinkers for cell expansion and ea...
15004189 - Cell surface localization of heparanase on macrophages regulates degradation of extrace...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-05-10
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  103     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-01     Completed Date:  2007-09-20     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  547-51     Citation Subset:  IM    
Affiliation:
Department of Nutritional Sciences and Toxicology, University of California at Berkeley, Berkeley, California 94720-3104, USA. kvarady@nature.berkeley.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Biological Markers / blood
Body Weight / physiology
Caloric Restriction*
Cell Proliferation*
Eating / physiology
Fasting / physiology*
Insulin-Like Growth Factor I / metabolism*
Male
Mice
Mice, Inbred C57BL
Prostate / cytology*,  physiology
Random Allocation
Spleen / cytology*,  physiology
Chemical
Reg. No./Substance:
0/Biological Markers; 67763-96-6/Insulin-Like Growth Factor I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Mechanism of partial adaptation in airway smooth muscle after a step change in length.
Next Document:  Exercise modulates platelet-nasopharyngeal carcinoma cell aggregation and subsequent tissue factor a...