Document Detail

Dose-dependent increases in metallothionein synthesis in the lung and liver of paraquat-treated rats.
MedLine Citation:
PMID:  1846247     Owner:  NLM     Status:  MEDLINE    
Dose-dependent changes in the concentration of metallothionein-1 (MT-1) in rat tissues were determined following subcutaneous administration of paraquat (PQ), a superoxide radical-generating agent. At 24 hr after injection. MT-1 concentrations in the lung increased linearly with PQ dose. Concentrations in the liver increased with dose until a plateau was reached at a dose of 30 mg/kg body wt. In the kidneys, MT-1 concentrations did not increase even at high doses of PQ. Zn was the principal metal bound to MT in the liver. PQ-induced MT-1 synthesis may reflect de novo protein synthesis, since the increase in MT-1 in the liver was reduced by pretreatment of the rats with actinomycin D. Although MT-1 synthesis in the liver was well correlated with lipid peroxidation, as evaluated by measurement of thiobarbituric acid-reactive substances, there was no such correlation in the kidneys. PQ increased the lipid peroxidation in kidneys without any increase in MT-I content. The data suggest that enhanced lipid peroxidation is not necessarily related to the increased MT-1 synthesis caused by radical-generating agents.
M Sato
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Toxicology and applied pharmacology     Volume:  107     ISSN:  0041-008X     ISO Abbreviation:  Toxicol. Appl. Pharmacol.     Publication Date:  1991 Jan 
Date Detail:
Created Date:  1991-02-20     Completed Date:  1991-02-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0416575     Medline TA:  Toxicol Appl Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  98-105     Citation Subset:  IM    
Division of Environmental Pollution Research, Fukushima Medical College, Japan.
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MeSH Terms
Body Weight / drug effects
Dactinomycin / pharmacology
Dose-Response Relationship, Drug
Lipid Peroxidation
Liver / drug effects*,  metabolism
Lung / drug effects*,  metabolism
Metallothionein / biosynthesis*
Organ Size / drug effects
Paraquat / pharmacology*
Rats, Inbred Strains
Superoxides / metabolism
Zinc / metabolism
Reg. No./Substance:
11062-77-4/Superoxides; 4685-14-7/Paraquat; 50-76-0/Dactinomycin; 7440-66-6/Zinc; 9038-94-2/Metallothionein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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