Document Detail

Dose-dependent frontal hypometabolism on FDG-PET in methamphetamine abusers.
MedLine Citation:
PMID:  19394959     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Although a lot of evidence from neuropsychological and neuroimaging studies supports the view that patients with substance dependence have abnormalities in the prefrontal cortex, functional deficits in the prefrontal cortex have not been fully investigated in methamphetamine (MA) dependent patients. This study was prepared to examine whether MA abusers have cerebral metabolic abnormalities and executive dysfunction. METHOD: Twenty-four abstinent MA dependent patients and 21 age-matched control subjects underwent resting brain FDG-PET and completed computerized versions of the Wisconsin card sorting test (WCST). Resting brain PET images were obtained 30min after an intravenous injection of 370MBq of (18)F-FDG. Significant differences in glucose metabolism were estimated for every voxel using t-statistics on SPM2 implemented in Matlab. RESULTS: Resting brain FDG-PET revealed significant hypometabolism in the left inferior frontal white matter (Talairach coordinates (x, y, z): -34, 7, 31) in MA dependent patients compared to the control subjects (corrected p=0.001, peak Z=5.37, voxel number 201). The nearest gray matter region was the left inferior frontal cortex (Brodmann area 9). There were negative correlations between the relative regional cerebral metabolism for glucose (rCMRglc) in the left inferior frontal white matter and the total cumulative dose of MA (r=-0.57, p<0.01). MA dependent patients completed significantly fewer categories (3.8+/-2.2) and made more perseveration errors (21.3+/-11.8) and total errors (43.5+/-19.5) on the WCST when compared to the control subjects (p<0.01). CONCLUSIONS: These data suggest that MA dependent patients have dose-dependent frontal hypometabolism and frontal executive dysfunction.
Yang-Tae Kim; Sang-Woo Lee; Do-Hoon Kwon; Ji-Hyoung Seo; Byeong-Cheol Ahn; Jaetae Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-04-23
Journal Detail:
Title:  Journal of psychiatric research     Volume:  43     ISSN:  1879-1379     ISO Abbreviation:  J Psychiatr Res     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-09-21     Completed Date:  2009-11-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376331     Medline TA:  J Psychiatr Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1166-70     Citation Subset:  IM    
Department of Psychiatry, Bugok National Hospital, Republic of Korea.
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MeSH Terms
Amphetamine-Related Disorders / complications,  pathology*,  radionuclide imaging*
Brain Mapping
Case-Control Studies
Cognition Disorders / etiology,  pathology,  radionuclide imaging
Dose-Response Relationship, Drug
Fluorodeoxyglucose F18 / diagnostic use*
Frontal Lobe / physiopathology*,  radionuclide imaging*
Neuropsychological Tests
Positron-Emission Tomography / methods
Statistics, Nonparametric
Reg. No./Substance:
63503-12-8/Fluorodeoxyglucose F18

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