Document Detail


Dose-dependent effects of sertoli cell toxicants 2,5-hexanedione, carbendazim, and mono-(2-ethylhexyl) phthalate in adult rat testis.
MedLine Citation:
PMID:  17763286     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sertoli cells are the primary cellular target for a number of pharmaceutical and environmental testicular toxicants, including 2,5-hexanedione, carbendazim, and mono-(2-ethylhexyl) phthalate. Exposure to these individual compounds can result in impaired Sertoli cell function and subsequent germ cell loss. The loss of testicular function is marked by histopathological changes in seminiferous tubule diameter, seminiferous epithelial sloughing, vacuolization, spermatid head retention, germ cell apoptosis, and altered microtubule assembly. The present study investigates dose-response relationships for these classic Sertoli cell toxicants using histopathology endpoints. Understanding the relationship between the Sertoli cell toxicant dose and its histopathologic manifestations will help establish the sensitivity of these endpoints as markers of testicular injury. The results indicate that no single histopathology endpoint was sensitive on its own in identifying altered testicular morphology resulting from toxicant exposure. However, when multiple endpoints were combined dose-response relationships could be associated with incremental alterations in histopathology. The data generated from these experiments will be useful in further investigating the effects of Sertoli cell toxicant exposure in animal toxicity studies. In addition, this work is fundamental to a planned investigation of the histopathologic and gene expression changes associated with testicular toxicant co-exposures, which may occur both occupationally and environmentally.
Authors:
Jeffrey S Moffit; Bronwyn H Bryant; Susan J Hall; Kim Boekelheide
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Toxicologic pathology     Volume:  35     ISSN:  0192-6233     ISO Abbreviation:  Toxicol Pathol     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-31     Completed Date:  2007-11-02     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  7905907     Medline TA:  Toxicol Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  719-27     Citation Subset:  IM    
Affiliation:
Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis / drug effects
Benzimidazoles / toxicity*
Body Weight / drug effects
Carbamates / toxicity*
Diethylhexyl Phthalate / analogs & derivatives*,  toxicity
Dose-Response Relationship, Drug
Hexanones / toxicity*
Male
Organ Size / drug effects
RNA, Messenger / analysis
Rats
Rats, Inbred F344
Sertoli Cells / drug effects*
Testis / drug effects,  metabolism,  pathology
Tubulin / genetics
Grant Support
ID/Acronym/Agency:
5P42 ES013660-02/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Benzimidazoles; 0/Carbamates; 0/Hexanones; 0/RNA, Messenger; 0/Tubulin; 110-13-4/2,5-hexanedione; 117-81-7/Diethylhexyl Phthalate; 4376-20-9/mono-(2-ethylhexyl)phthalate; H75J14AA89/carbendazim

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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