Document Detail

Dose-dependent effects of peptide YY(3-36) on conditioned taste aversion in rats.
MedLine Citation:
PMID:  16962209     Owner:  NLM     Status:  MEDLINE    
We used a conditioned taste aversion test to assess whether PYY(3-36) reduces food intake by producing malaise. Two-hour IV infusion of PYY(3-36) (8, 15, and 30 pmol/kg/min) at dark onset in non-food-deprived rats produced a dose-dependent inhibition of feeding and a conditioned aversion to the flavored chow paired with PYY(3-36) infusion. In food-deprived rats, PYY(3-36) at 2 and 4 pmol/kg/min inhibited intake of a flavored saccharin solution without producing conditioned taste aversion, whereas higher doses (8 and 15 pmol/kg/min) inhibited saccharin intake and produced taste aversion. These results suggest that anorexic doses of PYY(3-36) may produce a dose-dependent malaise in rats, which is similar to that reported for PYY(3-36) infusion in humans. Previous studies have shown that PYY(3-36) potently inhibits gastric emptying, and that gut distention can produce a conditioned taste aversion. Thus, PYY(3-36) may produce conditioned taste aversion in part by slowing gastric emptying.
Prasanth K Chelikani; Alvin C Haver; Roger D Reidelberger
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2006-09-07
Journal Detail:
Title:  Peptides     Volume:  27     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-20     Completed Date:  2007-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3193-201     Citation Subset:  IM    
Department of Biomedical Sciences, Creighton University, Omaha, NE 68178, USA.
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MeSH Terms
Avoidance Learning / drug effects*
Conditioning, Operant
Dose-Response Relationship, Drug
Infusions, Intravenous
Peptide Fragments / administration & dosage,  physiology*
Peptide YY / administration & dosage,  physiology*
Rats, Sprague-Dawley
Taste / physiology*
Grant Support
Reg. No./Substance:
0/Peptide Fragments; 106388-42-5/Peptide YY

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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