| Dose-dependent effects of intracoronary verapamil on systemic and coronary hemodynamics. | |
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MedLine Citation:
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PMID: 11300366 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Calcium antagonists are used in interventional cardiology to prevent coronary vasoconstriction or to overcome the no-reflow phenomenon. The aim of the current study was to evaluate the dose-dependent effects of intracoronary verapamil on systemic and coronary hemodynamics. In 20 patients scheduled for routine coronary angiography, heart rate, blood pressure, and ECG recordings were recorded continuously and intracoronary flow velocity was obtained by intracoronary Doppler measurements in angiographically normal vessels. The cross-sectional area, measured by quantitative coronary angiography, allowed the calculation of coronary blood flow (CBF) and the coronary vascular resistance index (CVRI). Without premedication, increasing dosages of verapamil (0.01 mg, 0.1 mg, 1.0 mg, and 2.0 mg) were injected into the left coronary artery. Intracoronary verapamil administration led to a decrease in systemic blood pressure only after administration of 1.0 mg or 2.0 mg (change in mean arterial pressure: from 87.6 +/-14.6 mmHg to 80.1 +/- 14.9 mmHg and 78.5 +/- 13.9 mmHg, respectively; both P < 0.05) without a change in heart rate. Epicardial diameters of the left coronary artery increased only at dosages of 1.0 mg and 2.0 mg (from 2.14 +/- 0.4 mm to 2.22 +/- 0.3 mm, P < 0.01), whereas the coronary blood flow velocity increased significantly at the smallest dosage of 0.01 mg (from 19.9 +/- 8.7 cm/s to 33.2 +/- 14.9 cm/s, P < 0.001) and was further enhanced with increasing dosages. CBF increased and CVRI decreased at every dosage of verapamil compared with baseline values. CBF increased also after 0.1 mg (from 13.5 +/- 6.5 mL/min to 19.5 +/- 9.3 mL/min; P < 0.05), reaching a maximal effect after administration of 1.0 mg verapamil (26.3 +/- 16.1 mL/min, P < 0.05). Application of 2.0 mg did not further increase CBF compared with 1.0 mg. Intracoronary application of verapamil leads to a decrease in systemic blood pressure at higher dosages, whereas heart rate remains unchanged at any dosage. The maximal increase in coronary blood flow and decrease in vascular resistance can be reached by administration of 1.0 mg verapamil into the left coronary artery. |
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Authors:
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O Oldenburg; H Eggebrecht; J Herrmann; C K Naber; M Haude; R Erbel; D Baumgart |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy Volume: 14 ISSN: 0920-3206 ISO Abbreviation: Cardiovasc Drugs Ther Publication Date: 2000 Dec |
Date Detail:
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Created Date: 2001-04-12 Completed Date: 2001-07-19 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8712220 Medline TA: Cardiovasc Drugs Ther Country: United States |
Other Details:
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Languages: eng Pagination: 651-5 Citation Subset: IM |
Affiliation:
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Department of Cardiology, University of Essen, Germany. olaf.oldenburg@uni-essen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Calcium Channel Blockers / administration & dosage, pharmacology* Coronary Angiography Coronary Circulation / drug effects* Coronary Vessels / anatomy & histology, drug effects Dose-Response Relationship, Drug Echocardiography, Doppler Female Heart Catheterization Hemodynamics / drug effects* Humans Male Middle Aged Verapamil / administration & dosage, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channel Blockers; 52-53-9/Verapamil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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