Document Detail

Dose-dependent effects of docosahexaenoic acid-rich fish oil on erythrocyte docosahexaenoic acid and blood lipid levels.
MedLine Citation:
PMID:  17977469     Owner:  NLM     Status:  MEDLINE    
Consumption of long-chain n-3 PUFA, particularly DHA, has been shown to improve cardiovascular risk factors but the intake required to achieve benefits is unclear. We sought to determine the relationship between DHA intake, increases in erythrocyte DHA content and changes in blood lipids. A total of sixty-seven subjects (thirty-six male, thirty-one female, mean age 53 years) with fasting serum TAG > or = 1.1 mmol/l and BMI>25 kg/m(2) completed a 12-week, randomized, double-blind, placebo-controlled parallel intervention. Subjects consumed 2, 4 or 6 g/d of DHA-rich fish oil (26 % DHA, 6 % EPA) or a placebo (Sunola oil). Fasting blood lipid concentrations and fatty acid profiles in erythrocyte membranes were assessed at baseline and after 6 and 12 weeks. For every 1 g/d increase in DHA intake, there was a 23 % reduction in TAG (mean baseline concentration 1.9 (sem 0.1) mmol/l), 4.4 % increase in HDL-cholesterol and 7.1 % increase in LDL-cholesterol. Erythrocyte DHA content increased in proportion to the dose of DHA consumed (r 0.72, P < 0.001) and the increase after 12 weeks was linearly related to reductions in TAG (r - 0.38, P < 0.01) and increases in total cholesterol (r 0.39, P < 0.01), LDL-cholesterol (r 0.33, P < 0.01) and HDL-cholesterol (r 0.30, P = 0.02). The close association between incorporation of DHA in erythrocytes and its effects on serum lipids highlights the importance of erythrocyte DHA as an indicator of cardiovascular health status.
Catherine M Milte; Alison M Coates; Jonathan D Buckley; Alison M Hill; Peter R C Howe
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2007-10-31
Journal Detail:
Title:  The British journal of nutrition     Volume:  99     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-08     Completed Date:  2009-03-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  1083-8     Citation Subset:  IM    
Nutritional Physiology Research Centre and ATN Centre for Metabolic Fitness, University of South Australia, Adelaide, SA, Australia.
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MeSH Terms
Docosahexaenoic Acids / administration & dosage,  blood,  pharmacology*
Dose-Response Relationship, Drug
Double-Blind Method
Erythrocytes / drug effects*,  metabolism
Fasting / blood
Fish Oils / administration & dosage,  pharmacology*
Lipids / blood
Middle Aged
Reg. No./Substance:
0/Fish Oils; 0/Lipids; 25167-62-8/Docosahexaenoic Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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