| Dose-dependent effects of bupivacaine on rat muscle arterioles. | |
| | |
MedLine Citation:
|
PMID: 3740507 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The dose-dependent actions of bupivacaine on the microvasculature were evaluated by television microscopy in an in vivo rat cremaster muscle preparation. Animals were anesthetized with chloralose and urethane. Mean arterial pressure was measured via a carotid artery cannula; heart rate was calculated from the phasic pressure trace. The cremaster muscle was suffused with a balanced electrolyte solution that was controlled for temperature, pH, PO2, PCO2, and osmolarity to provide a physiologic environment. Internal diameters of fourth-order arterioles were measured with an electronic vernier displayed on the video monitor. Arteriolar diameters were measured every 30 s during a 10-min control period, a 10-min period of topical application of bupivacaine hydrochloride, and a 30-min recovery period. Bupivacaine 10(-1), 10(0), 10(1), and 10(2) micrograms X ml-1 produced progressive vasoconstriction to 82.7 +/- 2.9%, 75.0 +/- 5.6%, 71.0 +/- 7.0%, and 65.7 +/- 9.4% of control (P less than 0.05 for each), respectively. Bupivacaine, 10(3) and 2.5 X 10(3) micrograms X ml-1, did not alter arteriolar diameters significantly, although there was a tendency for vasodilation. In a second group of animals, arteriolar diameters were measured during intravenous bupivacaine infusion that produced stable plasma concentrations of 2.3 +/- 0.2 micrograms X ml-1. Vasoconstriction of 91.4 +/- 2.2%, of control (P less than 0.01) was observed. These results demonstrate that dose-dependent arteriolar constriction occurs even with blood bupivacaine levels that are at the upper limits of those expected to occur during regional anesthesia. |
| | |
Authors:
|
R A Johns; W C Seyde; C A DiFazio; D E Longnecker |
Related Documents
:
|
20190767 - Kynurenine is an endothelium-derived relaxing factor produced during inflammation. 7447137 - Scanning electron microscopy of canine pulmonary arteries and veins. 12388247 - Effects of ischemia and myogenic activity on active and passive mechanical properties o... 15128467 - Vascular abnormalities in hypertension: cause, effect, or therapeutic target? 7105437 - Possible mechanisms of sodium-dependent hypertension: volume expansion or vasoconstrict... 2952817 - Pulmonary arterial pressure and plasma concentration of atrial natriuretic factor (anf)... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Anesthesiology Volume: 65 ISSN: 0003-3022 ISO Abbreviation: Anesthesiology Publication Date: 1986 Aug |
Date Detail:
|
Created Date: 1986-09-17 Completed Date: 1986-09-17 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 1300217 Medline TA: Anesthesiology Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 186-91 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Topical Animals Arteries / drug effects* Arterioles / drug effects* Blood Pressure / drug effects Bupivacaine / administration & dosage, pharmacology* Dose-Response Relationship, Drug Heart Rate / drug effects Injections, Intravenous Male Microcirculation / drug effects Microscopy Muscles / blood supply* Rats Rats, Inbred Strains Vascular Resistance / drug effects Vasoconstriction / drug effects |
| Chemical | |
Reg. No./Substance:
|
2180-92-9/Bupivacaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Dose-response effects of intravenous ranitidine on gastric pH and volume in outpatients.
Next Document: Nitrous oxide withdrawal reduces intracranial pressure in the presence of pneumocephalus.