Document Detail

Dose-dependent effects of angiotensin II on the ovine fetal cardiovascular system.
MedLine Citation:
PMID:  1957889     Owner:  NLM     Status:  MEDLINE    
The purpose of this experiment was to establish dose-response relationships for the effects of angiotensin II on arterial pressure, venous pressure, heart rate, and blood volume in the ovine fetus. Chronically catheterized fetal sheep at 132 +/- 1 (SE) days' gestational age were infused with angiotensin II at 4.8 +/- 1.1 (n = 7), 27.7 +/- 4.6 (n = 7), 102.2 +/- 16.7 (n = 6), or 239.0 +/- 30.9 (n = 4) ng/min/kg fetal body weight for 30 minutes. Fetal arterial pressure increased at the three highest doses. Fetal venous pressure, heart rate, and blood volume responded only at 102.2 and 239.0 ng/min/kg. At 239.0 ng/min/kg, arterial pressure increased by 17.7 +/- 1.6 mm Hg (p less than 0.00001), venous pressure increased by 1.5 +/- 0.3 mm Hg (p less than 0.0005), blood volume decreased by 7.8 +/- 2.2% (p less than 0.0001), and heart rate initially decreased by 14 +/- 4 beats/min, followed by an increase of 52 +/- 17 beats/min from control (p less than 0.0005) at the end of angiotensin II infusion. Thus this study shows that angiotensin II affected multiple fetal cardiovascular variables in a dose-dependent manner, suggesting that it is an important regulatory hormone for the entire fetal cardiovascular system.
O W Jones; C Y Cheung; R A Brace
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  165     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1991 Nov 
Date Detail:
Created Date:  1991-12-27     Completed Date:  1991-12-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1524-33     Citation Subset:  AIM; IM    
Department of Reproductive Medicine, University of California, San Diego, La Jolla 92093-0802.
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MeSH Terms
Angiotensin II / pharmacology*
Blood Pressure / drug effects
Blood Proteins / drug effects
Blood Volume / drug effects
Carbon Dioxide / blood
Cardiovascular System / drug effects*
Chlorine / blood
Dose-Response Relationship, Drug
Fetal Blood / chemistry
Heart Rate, Fetal / drug effects
Hydrogen-Ion Concentration
Osmolar Concentration
Oxygen / blood
Potassium / blood
Regression Analysis
Sodium / blood
Grant Support
Reg. No./Substance:
0/Blood Proteins; 11128-99-7/Angiotensin II; 124-38-9/Carbon Dioxide; 7440-09-7/Potassium; 7440-23-5/Sodium; 7782-44-7/Oxygen; 7782-50-5/Chlorine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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