| DOSE-DEPENDENT ANALYSIS OF ACUTE MEDICAL EFFECTS OF MIXED NEUTRON-GAMMA RADIATION FROM SELECTED SEVERE 235U OR 239Pu CRITICALITY ACCIDENTS IN USSR, UNITED STATES, AND ARGENTINA. | |
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MedLine Citation:
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PMID: 22378200 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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ABSTRACT: Eight of the most severe cases of acute radiation disease (ARS) known to have occurred in humans (as the result of criticality accidents) had survival times less than 120 h (herein defined as "early death"). These accidents were analyzed and are discussed with respect to the specific accident scenarios and the resulting accident-specific, mixed neutron-gamma radiation clinical dose distributions. This analysis concludes that the cardiovascular system appears to be the most critical organ system failure for causing "early death" following approximate total body, mixed gamma-neutron radiation doses greater than 40-50 Gy. The clinical data also suggest that there was definite chest dose dependence in the resulting survival times for these eight workers, who unfortunately suffered profound radiation injury and unusual clinical effects from such high dose radiation exposures. In addition, "toxemic syndrome" is correlated with the irradiation of large volumes of soft tissues. Doses to the hands or legs greater than 80-100 Gy or radiation lung injury also play significant but secondary roles in causing "early death" in accidents delivering chest doses greater than 50 Gy. |
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Authors:
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Tatyana Barabanova; Albert L Wiley; Andrey Bushmanov |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Health physics Volume: 102 ISSN: 1538-5159 ISO Abbreviation: Health Phys Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-03-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985093R Medline TA: Health Phys Country: United States |
Other Details:
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Languages: eng Pagination: 391-9 Citation Subset: IM |
Affiliation:
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*Burnasyan Federal Medical Biophysical Center of the Federal Medical Biological Agency (FMBC-FMBA), Moscow, Russia; †Radiation Emergency Assistance Center/Training Site (REAC/TS), ORISE, ORAU, Oak Ridge, TN. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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