Document Detail


Dose-dependent acute effects of recombinant human TSH (rhTSH) on thyroid size and function: comparison of 0.1, 0.3 and 0.9 mg of rhTSH.
MedLine Citation:
PMID:  19508679     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONTEXT: Recombinant human TSH (rhTSH) is used to augment the effect of radioiodine therapy for nontoxic multinodular goitre. Reports of acute thyroid swelling and hyperthyroidism warrant safety studies evaluating whether these side-effects are dose dependent. OBJECTIVE: To determine the effects on thyroid size and function of various doses of rhTSH. DESIGN: In nine healthy male volunteers, the effect of placebo, 0.1, 0.3 and 0.9 mg of rhTSH was examined in a paired design including four consecutive study rounds. MAIN OUTCOME MEASURES: Main outcome measures were evaluated at baseline, 24 h, 48 h, 96 h, 7 days and 28 days after rhTSH and included: Thyroid volume (TV) estimation by planimetric ultrasound, and thyroid function by serum TSH, free T3, free T4 and Tg levels. RESULTS: Following placebo or 0.1 mg rhTSH, the TV did not change significantly from baseline at any time. At 24 and 48 h after administration of 0.3 mg rhTSH, the TV increased by 37.4 +/- 12.3% (SEM) (P = 0.03) and 45.3 +/- 16.1% (P = 0.05) respectively. After 0.9 mg rhTSH, the TV increased by 23.3 +/- 5.8% (P = 0.008) and 35.5 +/- 18.4% (P = 0.02) respectively. The increase in serum FT3, FT4 and thyroglobulin (Tg) was greater when administering 0.3 mg compared with 0.1 mg (P = 0.02) and when administering 0.9 mg compared with 0.3 mg (P = 0.02). After 0.1 mg rhTSH, the increase in FT3 and Tg was not significantly different from placebo whereas the FT4 increase was significantly higher (P = 0.02 compared with placebo). CONCLUSIONS: In healthy individuals, rhTSH-induced thyroid swelling and hyperthyroidism is rapid and dose dependent. If valid for patients with goitre, our results suggest that these adverse effects are unlikely to be of clinical significance, following doses of rhTSH of 0.1 mg or less.
Authors:
S?ren Fast; Viveque E Nielsen; Steen J Bonnema; Laszlo Heged?s
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2009-06-08
Journal Detail:
Title:  Clinical endocrinology     Volume:  72     ISSN:  1365-2265     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-04-09     Completed Date:  2010-07-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  England    
Other Details:
Languages:  eng     Pagination:  411-6     Citation Subset:  IM    
Affiliation:
Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark. soeren.fast@ouh.regionsyddanmark.dk
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MeSH Terms
Descriptor/Qualifier:
Adult
Cross-Over Studies
Dose-Response Relationship, Drug
Double-Blind Method
Humans
Male
Middle Aged
Organ Size / drug effects
Recombinant Proteins / administration & dosage,  adverse effects
Thyroglobulin / blood
Thyroid Gland / drug effects*
Thyroid Hormones / blood
Thyrotropin / administration & dosage*,  adverse effects
Young Adult
Chemical
Reg. No./Substance:
0/Recombinant Proteins; 0/Thyroid Hormones; 9002-71-5/Thyrotropin; 9010-34-8/Thyroglobulin

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