Document Detail


Dose-dependent effects of ladostigil on microglial activation and cognition in aged rats.
MedLine Citation:
PMID:  23325108     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: Ladostigil (1 mg/kg/day) prevents the development of age-related memory deficits by a combination of immunomodulatory and antioxidant effects. A dose causing 30 % ChE inhibition is necessary in order to reverse existing memory deficits at 20 months of age.
Authors:
Marta Weinstock; Corina Bejar; Donna Schorer-Apelbaum; Rony Panarsky; Lisandro Luques; Shai Shoham
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-17
Journal Detail:
Title:  Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology     Volume:  8     ISSN:  1557-1904     ISO Abbreviation:  J Neuroimmune Pharmacol     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-28     Completed Date:  2013-08-16     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  101256586     Medline TA:  J Neuroimmune Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  345-55     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aging / drug effects*,  pathology*
Animals
Antigens, CD11b / metabolism
Antigens, CD3 / metabolism
Brain / pathology
Cholinesterase Inhibitors / pharmacology*
Cholinesterases / metabolism
Cognition / drug effects*
Dose-Response Relationship, Drug
Enzyme-Linked Immunosorbent Assay
Indans / pharmacology*
Interferon-gamma / metabolism
Killer Cells, Natural / metabolism
Macrophage Activation / drug effects*
Male
Maze Learning / drug effects
Memory, Long-Term / drug effects
Microglia / drug effects*
Monoamine Oxidase / metabolism
Rats
Rats, Wistar
Recognition (Psychology) / drug effects
Spleen / cytology,  drug effects
Th1 Cells / metabolism
Chemical
Reg. No./Substance:
0/(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate; 0/Antigens, CD11b; 0/Antigens, CD3; 0/Cholinesterase Inhibitors; 0/Indans; 82115-62-6/Interferon-gamma; EC 1.4.3.4/Monoamine Oxidase; EC 3.1.1.8/Cholinesterases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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