Document Detail


Dose accuracy of a durable insulin pen with memory function, before and after simulated lifetime use and under stress conditions.
MedLine Citation:
PMID:  23330725     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective: The objective of this study was to assess the dose accuracy of NovoPen® 5 in delivering low, medium and high doses of insulin before and after simulated lifetime use. A secondary objective was to evaluate the durability of the pen and its memory function under various stress conditions designed to simulate conditions that may be encountered in everyday use of an insulin pen. Research design and methods: All testing was conducted according to International Organization for Standardization guideline 11608-1, 2000 for pen injectors. Dose accuracy was measured for the delivery of 1 unit (U) (10 mg), 30 U (300 mg) and 60 U (600 mg) test medium in standard, cool and hot conditions and before and after simulated lifetime use. Dose accuracy was also tested after preconditioning in dry heat storage; cold storage; damp cyclical heat; shock, bump and vibration; free fall and after electrostatic charge and radiated field test. Memory function was tested under all temperature and physical conditions. Results: NovoPen 5 maintained dosing accuracy and memory function at minimum, medium and maximum doses in standard, cool and hot conditions, stress tests and simulated lifetime use. The pens remained intact and retained dosing accuracy and a working memory function at all doses after exposure to variations in temperature and after physical challenge. Conclusions: NovoPen 5 was accurate at all doses tested and under various functionality tests. Its durable design ensured that the dose accuracy and memory function were retained under conditions of stress likely to be encountered in everyday use.
Authors:
Ligang Xue; Kristian Handberg Mikkelsen
Related Documents :
1792335 - Ovariectomized does do not require progesterone priming for oestrous behaviour.
1060785 - Effects of artificial light on the oestrous cycle of the mare.
8848595 - Ova recovery, and in vivo and in vitro fertilization of ova from ru486-treated pmsg/hcg...
16727215 - Induced ovulation in atlantic croaker (sciaenidae) using hcg and an lhrh analog: a prel...
25361165 - Comparison of f(ab')2 versus fab antivenom for pit viper envenomation: a prospective, b...
7844385 - Systemic immunoprophylaxis of nasal respiratory syncytial virus infection in cotton rats.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-19
Journal Detail:
Title:  Expert opinion on drug delivery     Volume:  -     ISSN:  1744-7593     ISO Abbreviation:  Expert Opin Drug Deliv     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101228421     Medline TA:  Expert Opin Drug Deliv     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Novo Nordisk A/S , Brennum Park, DK-3400, Hilleroed , Denmark +45 30792580 ; LGGX@novonordisk.com.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Identification of a novel HLA-DRB1 allele, DRB1*09:20, by sequence-based typing in an unrelated bone...
Next Document:  Multilayered Hierarchical Capsules Providing Cell Adhesion Sites.