Document Detail


Dose-titration effects of fish oil in osteoarthritic dogs.
MedLine Citation:
PMID:  20707845     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Food supplemented with fish oil improves clinical signs and weight bearing in dogs with osteoarthritis (OA).
OBJECTIVE: Determine whether increasing the amount of fish oil in food provides additional symptomatic improvements in OA.
ANIMALS: One hundred and seventy-seven client-owned dogs with stable chronic OA of the hip or stifle.
METHODS: Prospective, randomized clinical trial using pet dogs. Dogs were randomly assigned to receive the baseline therapeutic food (0.8% eicosopentanoic acid [EPA] + docosahexaenoic acid [DHA]) or experimental foods containing approximately 2- and 3-fold higher EPA+DHA concentrations. Both veterinarians and owners were blinded as to which food the dog received. On days 0, 21, 45, and 90, serum fatty acid concentrations were measured and veterinarians assessed the severity of 5 clinical signs of OA. At the end of the study (day 90), veterinarians scored overall arthritic condition and progression of arthritis based on their clinical signs and an owner interview.
RESULTS: Serum concentrations of EPA and DHA rose in parallel with food concentrations. For 2 of 5 clinical signs (lameness and weight bearing) and for overall arthritic condition and progression of arthritis, there was a significant improvement between the baseline and 3X EPA+DHA foods (P=.04, .03, .001, .0008, respectively) but not between the baseline and the 2X EPA+DHA foods.
CONCLUSIONS AND CLINICAL IMPORTANCE: Increasing the amount of fish oil beyond that in the baseline food results in dose-dependent increases in serum EPA and DHA concentrations and modest improvements in the clinical signs of OA in pet dogs.
Authors:
D Fritsch; T A Allen; C E Dodd; D E Jewell; K A Sixby; P S Leventhal; K A Hahn
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-08-12
Journal Detail:
Title:  Journal of veterinary internal medicine / American College of Veterinary Internal Medicine     Volume:  24     ISSN:  0891-6640     ISO Abbreviation:  J. Vet. Intern. Med.     Publication Date:    2010 Sep-Oct
Date Detail:
Created Date:  2010-10-04     Completed Date:  2010-11-16     Revised Date:  2012-11-09    
Medline Journal Info:
Nlm Unique ID:  8708660     Medline TA:  J Vet Intern Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1020-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 by the American College of Veterinary Internal Medicine.
Affiliation:
Hill's Pet Nutrition Inc, Topeka, KS 4Clinics, Paris, France. dale_fritsch@hills.pet.com
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MeSH Terms
Descriptor/Qualifier:
Animal Feed / analysis
Animals
Diet / veterinary
Dog Diseases / drug therapy*
Dogs
Dose-Response Relationship, Drug
Fatty Acids / blood
Female
Fish Oils / administration & dosage*,  therapeutic use*
Lameness, Animal / drug therapy
Male
Osteoarthritis / drug therapy,  veterinary*
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Fish Oils
Comments/Corrections
Comment In:
J Vet Intern Med. 2012 Sep-Oct;26(5):1083-4; author reply 1085-6   [PMID:  22845685 ]
Erratum In:
J Vet Intern Med. 2011 Jan-Feb;25(1):167

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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