Document Detail

Dose-Dependent Hemodynamic and Metabolic Effects of Vasoactive Medications in Normotensive, Anesthetized Neonatal Piglets.
MedLine Citation:
PMID:  21775923     Owner:  NLM     Status:  Publisher    
The developmentally regulated hemodynamic effects of vasoactive medications have not been well characterized. We utilized traditional and near infrared spectroscopy monitoring technologies and investigated the changes in heart rate, blood pressure, common carotid artery (CCA) blood flow (BF), cerebral, renal, intestinal and muscle regional tissue O2 saturation and acid-base and electrolyte status in response to escalating doses of vasoactive medications in normotensive anesthetized neonatal piglets. We used regional tissue O2 saturation and CCA BF as surrogates of organ and systemic BF, respectively and controlled minute ventilation and oxygenation. Low- to medium-doses of dopamine, epinephrine, dobutamine and norepinephrine increased blood pressure and systemic and regional BF in a drug-specific manner while milrinone exerted minimal effects. At higher doses, dopamine, epinephrine and norepinephrine but not dobutamine decreased systemic, renal, intestinal, and muscle BF while cerebral BF remained unchanged. Epinephrine induced significant increases in muscle BF, and serum glucose and lactate concentrations. The findings reveal novel drug- and dose-specific differences in the hemodynamic response to escalating doses of vasoactive medications in the neonatal cardiovascular system and provide information for future clinical studies investigating the use of vasoactive medications for the treatment of neonatal cardiovascular compromise. ABBREVIATIONS::
Raul A Nachar; Erin A Booth; Philippe Friedlich; Matthew Borzage; Sadaf Soleymani; Michael D Wider; Istvan Seri
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-19
Journal Detail:
Title:  Pediatric research     Volume:  -     ISSN:  1530-0447     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Pediatrics [R.A.N.], Clinica Alemana, Santiago de Chile 1900, Chile; Department of Physiology [M.D.W.], Wayne State University School of Medicine, Detroit, MI 48201; Somanetics Corp. [E.A.B., M.D.W.], Troy, MI 48084; Department of Pediatrics [P.F., M.B., S.S., I.S.], Children's Hospital Los Angeles and the LAC+USC Medical Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027; Department of Bioengineering [M.B., S.S.], Viterbi School of Engineering, University of Southern California, Los Angeles, CA 90089.
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