Document Detail

Dose-dependent consumption of farmed Atlantic salmon (Salmo salar) increases plasma phospholipid n-3 fatty acids differentially.
MedLine Citation:
PMID:  23351633     Owner:  NLM     Status:  MEDLINE    
Enhanced n-3 fatty acid intake benefits cardiovascular disease (CVD) risk reduction. Increasing consumption at a population level may be better addressed by diet than through supplementation. However, limited data are available on the effect of the dose response to fish intake on plasma levels of n-3 fatty acids. To compare the effects of different doses of farmed Atlantic salmon on plasma phospholipid fatty acid proportions and CVD risk biomarkers (eg, glucose, insulin, homeostasis model of assessment-insulin resistance, high-sensitivity C-reactive protein, and interleukin-6) in healthy subjects we performed a randomized three-period crossover-designed trial (4-week treatment, 4- to 8-week washout) to compare the effects of twice per week consumption of farmed Atlantic salmon at doses of 90, 180, and 270 g in 19 apparently healthy men and women (mean age 40 to 65 years) and a body mass index between 25 and 34.9. All study visits were conducted at the US Department of Agriculture Agricultural Research Service Grand Forks Human Nutrition Research Center. Eicosapentaenoic acid and total n-3 concentrations were increased (P<0.05) by all treatments in a dose-response manner, with total n-3 of 8.03% ± 0.26% and 9.21% ± 0.26% for 180- and 270-g doses, respectively. Linoleic acid did not change in response to treatment, whereas arachidonic acid (P<0.05) and total n-6 fatty acids decreased dose dependently (<0.0001). The addition of farmed Atlantic salmon to the diet twice per week for 4 weeks at portions of 180 g and 270 g modifies phospholipid fatty acid proportions of n-3 and n-6 in a level associated with decreased risk for CVD.
Susan K Raatz; Thad A Rosenberger; LuAnn K Johnson; William W Wolters; Gary S Burr; Matthew J Picklo
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of the Academy of Nutrition and Dietetics     Volume:  113     ISSN:  2212-2672     ISO Abbreviation:  J Acad Nutr Diet     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-28     Completed Date:  2013-03-14     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  101573920     Medline TA:  J Acad Nutr Diet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  282-7     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2013 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Biological Markers / blood
Body Mass Index
C-Reactive Protein / metabolism
Cardiovascular Diseases / blood*,  epidemiology,  prevention & control
Cross-Over Studies
Docosahexaenoic Acids / blood
Dose-Response Relationship, Drug
Eicosapentaenoic Acid / blood
Fatty Acids, Omega-3 / administration & dosage*,  blood*
Fatty Acids, Omega-6 / blood
Insulin / metabolism
Interleukin-6 / blood
Linoleic Acid / blood
Middle Aged
Salmo salar*
Triglycerides / blood
Grant Support
2P20RR017699-09/RR/NCRR NIH HHS; P20 RR017699/RR/NCRR NIH HHS
Reg. No./Substance:
0/Biological Markers; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 0/Insulin; 0/Interleukin-6; 0/Triglycerides; 25167-62-8/Docosahexaenoic Acids; 9007-41-4/C-Reactive Protein; 9KJL21T0QJ/Linoleic Acid; AAN7QOV9EA/Eicosapentaenoic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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