| Dosage frequency for suppression of platelet function by low dose aspirin therapy. | |
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MedLine Citation:
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PMID: 7123514 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A study of platelet aggregation and MDA production after an oral dose of 300 mg aspirin indicated that partial recovery of platelet function occurred when approximately one third of the circulating platelets had been replaced by new (uninhibited) platelets. In vitro studies on mixtures of normal and aspirin inhibited platelets indicated partial restoration of platelet aggregation and thromboxane B2 production with as little as 10% of normal platelets in some subjects. Restoration of full function required a higher proportion of normal platelets. There was considerable variation between subjects. These data suggest that complete suppression of platelet functions in all normal subjects requires daily administration of the drug. |
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Authors:
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B A Bradlow; N Chetty |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Thrombosis research Volume: 27 ISSN: 0049-3848 ISO Abbreviation: Thromb. Res. Publication Date: 1982 Jul |
Date Detail:
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Created Date: 1982-12-02 Completed Date: 1982-12-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0326377 Medline TA: Thromb Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 99-110 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Diphosphate
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pharmacology Aspirin / administration & dosage, pharmacology*, therapeutic use Cell Survival / drug effects Collagen / pharmacology Depression, Chemical Dose-Response Relationship, Drug Epinephrine / pharmacology Humans Malondialdehyde / biosynthesis Platelet Aggregation / drug effects* Platelet Function Tests Thrombosis / drug therapy Thromboxane B2 / biosynthesis |
| Chemical | |
Reg. No./Substance:
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50-78-2/Aspirin; 51-43-4/Epinephrine; 542-78-9/Malondialdehyde; 54397-85-2/Thromboxane B2; 58-64-0/Adenosine Diphosphate; 9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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