Document Detail

Dosage of digoxin in premature infants.
MedLine Citation:
PMID:  430313     Owner:  NLM     Status:  MEDLINE    
The pharmacokinetics and pharmacodynamics of digoxin in premature infants was studied. During maintenance therapy, after a total digitalizing dose of 30 microgram/kg, the measured digoxin level was related inversely to body weight at birth and to estimated gestational age. The serum digoxin levels found in the immature and smaller infants were two to three times the values usually reported to be toxic in older children. Based on these findings, a second group of premature infants was digitalized with 20 microgram/kg; in this group, the serum digoxin levels were below the toxic range, irrespective of gestational age or birth weight. The cardiac effects of digoxin, i.e., shortened left ventricular pre-ejection period and ejection time as determined by echocardiography, were similar in the two groups. For both groups, the half-life of digoxin in the serum was twice that reported for term infants and children. Since digitalis effect is obtained with lower dose and serum concentration, we recommend that this dose be used in premature infants.
W W Pinsky; J R Jacobsen; P C Gillette; J Adams; L Monroe; D G McNamara
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  94     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1979 Apr 
Date Detail:
Created Date:  1979-06-26     Completed Date:  1979-06-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  639-42     Citation Subset:  AIM; IM    
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MeSH Terms
Birth Weight
Digoxin / administration & dosage*,  metabolism,  pharmacology
Gestational Age
Heart Failure / drug therapy
Heart Ventricles / drug effects
Infant, Newborn
Infant, Premature, Diseases / drug therapy*,  metabolism
Prospective Studies
Reg. No./Substance:

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