Document Detail

Dorsomedial hypothalamic corticotropin-releasing factor mediation of exercise-induced anorexia.
MedLine Citation:
PMID:  15677523     Owner:  NLM     Status:  MEDLINE    
Running wheel access and resulting voluntary exercise alter food intake and reduce body weight. The neural mechanisms underlying these effects are unclear. In this study, we first assessed the effects of 7 days of running wheel access on food intake, body weight, and hypothalamic gene expression. We demonstrate that running wheel access significantly decreases food intake and body weight and results in a significant elevation of CRF mRNA expression in the dorsomedial hypothalamus (DMH) but not the paraventricular nucleus. Seven-day running wheel access also results in elevated arcuate nucleus and DMH neuropeptide Y gene expression. To assess a potential role for elevated DMH CRF activity in the activity-induced changes in food intake and body weight, we compared changes in food intake, body weight, and hypothalamic gene expression in rats receiving intracerebroventricular (ICV) CRF antagonist alpha-helical CRF or vehicle with or without access to running wheels. During a 4-day period of running wheel access, we found that exercise-induced reductions of food intake and body weight were significantly attenuated by ICV injection of the CRF antagonist. The effect on food intake was specific to a blockade of activity-induced changes in meal size. Central CRF antagonist injection further increased DMH CRF mRNA expression in exercised rats. Together, these data suggest that DMH CRF play a critical role in the anorexia resulting from increased voluntary exercise.
Maiko Kawaguchi; Karen A Scott; Timothy H Moran; Sheng Bi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-01-27
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  288     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-05-11     Completed Date:  2005-06-15     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R1800-5     Citation Subset:  IM    
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 720 Rutland Ave., Ross 618, Baltimore, MD 21205, USA.
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MeSH Terms
Body Weight / drug effects,  physiology
Corticotropin-Releasing Hormone / administration & dosage,  antagonists & inhibitors,  pharmacology*
Dorsomedial Hypothalamic Nucleus / physiology*
Eating / drug effects,  physiology*
Energy Metabolism / physiology
Hormone Antagonists / pharmacology
In Situ Hybridization
Injections, Intraventricular
Paraventricular Hypothalamic Nucleus / physiology
Peptide Fragments / pharmacology
Physical Exertion / physiology*
RNA Probes
RNA, Messenger / biosynthesis,  genetics
Rats, Sprague-Dawley
Reg. No./Substance:
0/Hormone Antagonists; 0/Peptide Fragments; 0/RNA Probes; 0/RNA, Messenger; 9015-71-8/Corticotropin-Releasing Hormone; 96118-75-1/corticotropin releasing hormone (9-41)

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