| Dorsal root tetrodotoxin-resistant sodium channels do not contribute to the augmented exercise pressor reflex in rats with chronic femoral artery occlusion. | |
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MedLine Citation:
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PMID: 21076028 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the contribution of tetrodotoxin (TTX)-resistant sodium channels to the augmented exercise pressor reflex observed in decerebrated rats with femoral artery ligation. The pressor responses to static contraction, to tendon stretch, and to electrical stimulation of the tibial nerve were compared before and after blocking TTX-sensitive sodium channels on the L3-L6 dorsal roots of rats whose hindlimbs were freely perfused and rats whose femoral arteries were ligated 72 h before the start of the experiment. In the freely perfused group (n=9), pressor (Δ22±4 mmHg) and cardioaccelerator (Δ32±6 beats/min) responses to contraction were attenuated by 1 μM TTX (Δ4±1 mmHg, P<0.05 and Δ17±4 beats/min, P<0.05, respectively). In the 72 h ligated group (n=9), the augmented pressor response to contraction (32±4 mmHg) was also attenuated by 1 μM TTX (Δ8±2 mmHg, P<0.05). The cardioaccelerator response to contraction was not significantly attenuated in these rats. In addition, TTX suppressed the pressor response to tendon stretch in both groups of rats. Electrical stimulation of the tibial nerve evoked similar pressor responses between the two groups (freely perfused: Δ74±9 mmHg and 72 h ligated: Δ78±5 mmHg). TTX attenuated the pressor response to the tibial nerve stimulation by about one-half in both groups. Application of the TTX-resistant sodium channel blocker A-803467 (1 μM) with TTX (1 μM) did not block the pressor response to tibial nerve stimulation to any greater extent than did application of TTX (1 μM) alone. Although the contribution of TTX-resistant sodium channels to the augmented exercise pressor reflex may be slightly increased in rats with chronic femoral artery ligation, TTX-resistant sodium channels on dorsal roots do not play a major role in the augmented exercise pressor reflex. |
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Authors:
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Hirotsugu Tsuchimochi; Jennifer L McCord; Anna K Leal; Marc P Kaufman |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-11-12 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 300 ISSN: 1522-1539 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-01 Completed Date: 2011-03-15 Revised Date: 2012-02-01 |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H652-63 Citation Subset: IM |
Affiliation:
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Pennsylvania State Heart and Vascular Institute, Pennsylvania State University College of Medicine, 500 Univ. Dr., Mail Code H047, Hershey Medical Center, Hershey, PA 17033, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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drug effects Animals Blood Pressure / physiology* Decerebrate State / physiopathology Dexamethasone / pharmacology Electric Stimulation Femoral Artery / physiology* Heart Rate / drug effects, physiology Hindlimb / blood supply, drug effects, physiology Ligation Male Muscle Contraction / drug effects Physical Conditioning, Animal / physiology* Physical Stimulation Rats Rats, Sprague-Dawley Regional Blood Flow / drug effects Sodium Channel Blockers / pharmacology* Sodium Channels / drug effects* Spinal Nerve Roots / drug effects, metabolism* Tendons / physiology Tetrodotoxin / pharmacology* Tibial Nerve / physiology |
| Grant Support | |
ID/Acronym/Agency:
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P0 1 HL-096570/HL/NHLBI NIH HHS; R01 AR-059397/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Sodium Channel Blockers; 0/Sodium Channels; 4368-28-9/Tetrodotoxin; 50-02-2/Dexamethasone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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