| Dorothy Hodgkin Lecture 2010. From hype to hope? A journey through the genetics of Type 2 diabetes. | |
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MedLine Citation:
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PMID: 21219419 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Recent advances in genetic analysis have enabled researchers to perform genome-wide surveys for common DNA sequence variants associated with risk of Type 2 diabetes and related traits. Over the past 4 years, these endeavours have extended the number of proven Type 2 diabetes-susceptibility loci from a handful to the current total of over 40. Each of these loci provides an opportunity to uncover insights into the biology of glucose regulation and the pathogenesis of Type 2 diabetes, insights which should support clinical translation to identify novel ways of treating and preventing disease. Here, I describe (i) progress in identification of diabetes-susceptibility loci; (ii) biological insights that have been gained in the relatively short period since these loci were discovered; and (iii) the challenges that need to be addressed if we are to maximize the translational benefits of this research. |
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Authors:
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M I McCarthy |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Diabetic medicine : a journal of the British Diabetic Association Volume: 28 ISSN: 1464-5491 ISO Abbreviation: Diabet. Med. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8500858 Medline TA: Diabet Med Country: England |
Other Details:
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Languages: eng Pagination: 132-40 Citation Subset: IM |
Copyright Information:
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© 2011 The Author. Diabetic Medicine © 2011 Diabetes UK. |
Affiliation:
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Oxford Centre for Diabetes, Endocrinology and Metabolism, Wellcome Trust Centre for Human Genetics, University of Oxford and Oxford NIHR Biomedical Research Centre, Churchill Hospital, Old Road, Headington, Oxford, UK. mark.mccarthy@drl.ox.ac.uk |
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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//Medical Research Council; //Wellcome Trust |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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