Document Detail


Dopplersonographic measurement of global cerebral circulation time using echo contrast-enhanced ultrasound in normal individuals and patients with arteriovenous malformations.
MedLine Citation:
PMID:  12049958     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Echo-contrast "bolus tracking" by ultrasound (US) is an exciting new tool to study cerebral haemodynamics. In the present study, a global cerebral circulation time (CCT) was measured by extracranial Doppler as the time difference of contrast bolus arrival between the internal carotid artery and internal jugular vein. A total of 64 healthy volunteers and 9 patients with an angiographically diagnosed arteriovenous malformation (AVM) were studied. CCT in volunteers and patients was calculated as the time interval between the points of 10% rise (CCT(1)) and 90% rise (CCT(3)) of the total intensity increase and between the turning points (CCT(2)) of the resulting time-intensity curves. In the volunteer group, CCT(1) was 5.4 +/- 1.8 s, CCT(2) was 7 +/- 1.3 s and CCT(3) 7.5 +/- 1.8 s. CCT results in the AVM group were 2.8 +/- 2.5 s, 3.0 +/- 1.3 s and 4.5 +/- 2.1 s, respectively, and differed significantly from the controls. For the first time, we could confirm a significant shortening of CCT in patients with cerebral AVM by US. The presented test might become a new, additional tool for AVM evaluation and follow-up of treatment in these patients.
Authors:
Stephan Joachim Schreiber; Uwe Franke; Florian Doepp; Elda Staccioli; Kamil Uludag; José Manuel Valdueza
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Ultrasound in medicine & biology     Volume:  28     ISSN:  0301-5629     ISO Abbreviation:  Ultrasound Med Biol     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-06-06     Completed Date:  2002-08-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0410553     Medline TA:  Ultrasound Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  453-8     Citation Subset:  IM    
Affiliation:
Department of Neurology, University Hospital Charité, Schumannstrasse 20/21, 10098 Berlin, Germany. Stephan.Schreiber@charite.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blood Circulation Time
Carotid Artery, Internal / ultrasonography
Cerebrovascular Circulation / physiology*
Contrast Media
Female
Humans
Intracranial Arteriovenous Malformations / physiopathology*,  radiography,  ultrasonography*
Jugular Veins / ultrasonography
Male
Middle Aged
Sensitivity and Specificity
Ultrasonography, Doppler, Transcranial / methods*
Chemical
Reg. No./Substance:
0/Contrast Media

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