Document Detail

Doppler umbilical and uterine flow waveforms in severe pregnancy hypertension.
MedLine Citation:
PMID:  2180475     Owner:  NLM     Status:  MEDLINE    
Doppler studies of the umbilical and uteroplacental bed arterial flow velocity waveforms were performed in a series of women suffering from severe proteinuric pregnancy hypertension. Ninety-five women were studied and the mean interval between the last study and delivery was 1.4 days. An abnormally elevated umbilical artery systolic:diastolic (AB) ratio was present in 61 (64%) of the women. All 10 perinatal deaths were associated with pregnancies with an abnormal umbilical artery AB ratio. An elevated umbilical artery AB ratio was significantly associated with small-for-gestation and neonatal morbidity. Infants associated with extremely high umbilical artery AB ratios (greater than or equal to 99th centile) spent twice as long in the neonatal nursery as those with a lower value. There was no relation between the duration of hypertension and the umbilical study result. The uteroplacental bed artery flow velocity waveform did not correlate with fetal or neonatal mortality or morbidity. Patients with abnormal uteroplacental AB ratios also had abnormal umbilical artery AB ratios. We conclude that an abnormal fetal umbilical artery Doppler flow velocity waveform correlates with adverse fetal outcome in severe proteinuric pregnancy hypertension and suggest that the associated placental lesion may precede the maternal hypertension.
B J Trudinger; C M Cook
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of obstetrics and gynaecology     Volume:  97     ISSN:  0306-5456     ISO Abbreviation:  Br J Obstet Gynaecol     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-05-08     Completed Date:  1990-05-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503752     Medline TA:  Br J Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  142-8     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynaecology, University of Sydney, Westmead Hospital, NSW, Australia.
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MeSH Terms
Blood Flow Velocity
Fetal Growth Retardation / physiopathology
Gestational Age
Hypertension / physiopathology*
Infant, Newborn
Infant, Small for Gestational Age
Pregnancy Complications, Cardiovascular / physiopathology*
Pregnancy Outcome
Time Factors
Umbilical Arteries / physiopathology*
Uterus / blood supply*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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