Document Detail


Doppler ultrasound of the hepatic artery and vein performed daily in the first two weeks after orthotopic liver transplantation. Useful for the diagnosis of acute rejection?
MedLine Citation:
PMID:  8675425     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RATIONALE AND OBJECTIVES: To analyze changes in Doppler ultrasound variables in relation to liver biopsy findings for the diagnosis of acute rejection after orthotopic liver transplantation (OLT), the authors performed in a prospective study 316 Doppler ultrasound examinations in the first 2 weeks after OLT on 23 patients. METHODS: Recordings were obtained daily from the hepatic artery (resistive index [RI]) and hepatic vein (damping index [DI]). Correlations were explored between the Doppler ultrasound findings and histologic data. The chi-square test was used to analyze differences in Doppler ultrasound variables in patients with and without acute rejection. RESULTS: Serial Doppler ultrasound examinations showed a significant increase in the RI in 11 of 22 patients (50%); the 23rd patient was excluded because of hepatic artery thrombosis. Despite an agreement in 15 of 22 patients (68%) no statistically significant correlation could be found (positive predictive value 6/11 = 55%; negative predictive value 9/11 = 82%; chi-square = 3.14; P > 0.05). A significant increase in the DI was observed in 14 of 23 patients (61%). However, no statistically significant correlation could be found as well with this parameter (positive predictive value 6/14 = 43%; negative predictive value 6/9 = 67%; chi-square = 0.00; P > 0.05). CONCLUSION: Serial Doppler ultrasound examinations were not helpful in predicting acute rejection.
Authors:
T Kok; E B Haagsma; I J Klompmaker; J H Zwaveling; P M Peeters; C M Bijleveld; L Meerman; M J Slooff
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Investigative radiology     Volume:  31     ISSN:  0020-9996     ISO Abbreviation:  Invest Radiol     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-08-14     Completed Date:  1996-08-14     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0045377     Medline TA:  Invest Radiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  173-9     Citation Subset:  IM    
Affiliation:
Department of Diagnostic Radiology, University Hospital Groningen, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adolescent
Adult
Biopsy
Case-Control Studies
Child
Child, Preschool
Graft Rejection / pathology,  ultrasonography*
Hepatic Artery / ultrasonography*
Hepatic Veins / ultrasonography*
Humans
Infant
Liver Transplantation / pathology,  ultrasonography*
Middle Aged
Predictive Value of Tests
Prospective Studies
Time Factors
Ultrasonography, Doppler

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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