| Doppler mode pulse sequences mitigate glomerular capillary hemorrhage in contrast-aided diagnostic ultrasound of rat kidney. | |
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MedLine Citation:
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PMID: 17941386 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glomerular capillary hemorrhage (GCH) induced in rat kidney by diagnostic ultrasound involving contrast agent destruction was characterized for different modes to explore possible mitigation strategies. Anesthetized hairless rats were scanned at 2.5 MHz in a water bath with contrast agent infused at 10 microl/kg/minute via tail vein. B mode flash echo imaging (FEI), color Doppler (CD) FEI and realtime Doppler imaging at 1 frame per second were tested, which had image pulse sequences of approximately 0.53 ms, 15.8 ms, and 83.5 ms duration, respectively. Bioeffects endpoints included grossly observed blood-filled tubules, histological evaluation of GCH, and detection of hematuria. B mode FEI for 1 minute induced GCH in 38.6+/-17.1% of glomeruli in histology from the scan plane for a peak rarefactional pressure amplitude (RPA) of 2.6 MPa. The threshold for GCH was approximately 1.5 MPa, confirmed by 10-minute exposure with agent infusion. Paradoxically, CD mode FEI delivered many more pulses but produced less GCH (P < 0.02), and real-time Doppler mode induced only 5.3 +/- 3.8% (P < 0.005). Hematuria results followed the GCH trends. These findings indicate a promising strategy, which is to use relatively slow ramp-up of pulse RPAs in agent-destroying image pulse sequences, for mitigating potential bioeffects in contrastaided diagnostic ultrasound. |
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Authors:
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Douglas L Miller; Chunyan Dou; Roger C Wiggins |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: IEEE transactions on ultrasonics, ferroelectrics, and frequency control Volume: 54 ISSN: 0885-3010 ISO Abbreviation: IEEE Trans Ultrason Ferroelectr Freq Control Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-10-18 Completed Date: 2007-11-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9882735 Medline TA: IEEE Trans Ultrason Ferroelectr Freq Control Country: United States |
Other Details:
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Languages: eng Pagination: 1802-10 Citation Subset: IM |
Affiliation:
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University of Michigan Health Systems, Department of Radiology, Ann Arbor MI 48109-0553, USA. douglm@umich.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Capillaries / drug effects, ultrasonography Contrast Media / adverse effects* Dose-Response Relationship, Drug Echocardiography, Doppler, Pulsed / adverse effects, methods* Fluorocarbons / adverse effects*, diagnostic use Hemorrhage / chemically induced*, prevention & control, ultrasonography Image Enhancement / methods Kidney / blood supply, drug effects, ultrasonography* Kidney Diseases / chemically induced*, prevention & control, ultrasonography Rats |
| Grant Support | |
ID/Acronym/Agency:
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EB00338/EB/NIBIB NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Definity; 0/Fluorocarbons |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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