Document Detail

Doppler imaging predicts cardiac events in chronic pulmonary thromboembolism.
MedLine Citation:
PMID:  18242738     Owner:  NLM     Status:  MEDLINE    
PURPOSE: We evaluated whether right ventricular (RV) diastolic dysfunction assessed by pulsed tissue Doppler imaging (TDI) predicts cardiac events in patients with chronic pulmonary thromboembolism (CPTE). MATERIALS AND METHODS: In 63 consecutive patients with CPTE, early diastolic myocardial velocity (Ea) at the tricuspid annulus by TDI and early diastolic tricuspid inflow (E) by conventional pulsed Doppler were obtained, and E/Ea was calculated as an indicator of RV diastolic dysfunction. Brain natriuretic peptide (BNP) and other echo parameters were also obtained. A cardiac event (rehospitalization caused by congestive heart failure or cardiac death) was the study endpoint. Incidence of cardiac events was determined over a 374+/-451 day follow-up period. RESULTS: In the follow-up period twelve patients had cardiac events. We divided patients into group A with cardiac events and group B without events. E/Ea was significantly increased in group A as compared with group B (8.3+/-4.1 vs. 5.7+/-2.6, p<0.01). BNP was higher in group A than group B (221+/-191 vs. 121+/-140 mg/dl, p<0.05), and in addition E/Ea was significantly positively correlated with BNP (r=0.48, p<0.001). A logistic regression model for predicting cardiac events was constructed and E/Ea was associated with an increased incidence of cardiac events (relative risk=1.33, 95% CI 1.00-1.75). CONCLUSION: Elevated values of E/Ea obtained by TDI may predict cardiac events in patients with CPTE. BNP may also be a significant predictor.
Yumi Shiina; Nobusada Funabashi; Kwangho Lee; Masao Daimon; Tai Sekine; Miyuki Kawakubo; Yukiko Sekine; Maiko Takahashi; Rei Yajima; Yu Wakatsuki; Nobuhiro Tanabe; Takayuki Kuriyama; Issei Komuro
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Publication Detail:
Type:  Journal Article     Date:  2008-02-01
Journal Detail:
Title:  International journal of cardiology     Volume:  133     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-20     Completed Date:  2009-07-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  167-72     Citation Subset:  IM    
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Inohana 1-8-1, Chuo-ku, Chiba City, Chiba 260-8670, Japan.
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MeSH Terms
Biological Markers / blood
Chronic Disease
Echocardiography, Doppler, Pulsed
Heart Failure / epidemiology,  etiology
Middle Aged
Natriuretic Peptide, Brain / blood
Predictive Value of Tests
Pulmonary Embolism / blood,  complications*
Ventricular Dysfunction, Right / blood,  etiology,  ultrasonography*
Reg. No./Substance:
0/Biological Markers; 114471-18-0/Natriuretic Peptide, Brain

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