| Doppler imaging predicts cardiac events in chronic pulmonary thromboembolism. | |
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MedLine Citation:
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PMID: 18242738 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: We evaluated whether right ventricular (RV) diastolic dysfunction assessed by pulsed tissue Doppler imaging (TDI) predicts cardiac events in patients with chronic pulmonary thromboembolism (CPTE). MATERIALS AND METHODS: In 63 consecutive patients with CPTE, early diastolic myocardial velocity (Ea) at the tricuspid annulus by TDI and early diastolic tricuspid inflow (E) by conventional pulsed Doppler were obtained, and E/Ea was calculated as an indicator of RV diastolic dysfunction. Brain natriuretic peptide (BNP) and other echo parameters were also obtained. A cardiac event (rehospitalization caused by congestive heart failure or cardiac death) was the study endpoint. Incidence of cardiac events was determined over a 374+/-451 day follow-up period. RESULTS: In the follow-up period twelve patients had cardiac events. We divided patients into group A with cardiac events and group B without events. E/Ea was significantly increased in group A as compared with group B (8.3+/-4.1 vs. 5.7+/-2.6, p<0.01). BNP was higher in group A than group B (221+/-191 vs. 121+/-140 mg/dl, p<0.05), and in addition E/Ea was significantly positively correlated with BNP (r=0.48, p<0.001). A logistic regression model for predicting cardiac events was constructed and E/Ea was associated with an increased incidence of cardiac events (relative risk=1.33, 95% CI 1.00-1.75). CONCLUSION: Elevated values of E/Ea obtained by TDI may predict cardiac events in patients with CPTE. BNP may also be a significant predictor. |
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Authors:
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Yumi Shiina; Nobusada Funabashi; Kwangho Lee; Masao Daimon; Tai Sekine; Miyuki Kawakubo; Yukiko Sekine; Maiko Takahashi; Rei Yajima; Yu Wakatsuki; Nobuhiro Tanabe; Takayuki Kuriyama; Issei Komuro |
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Publication Detail:
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Type: Journal Article Date: 2008-02-01 |
Journal Detail:
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Title: International journal of cardiology Volume: 133 ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-03-20 Completed Date: 2009-07-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 167-72 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Inohana 1-8-1, Chuo-ku, Chiba City, Chiba 260-8670, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / blood Chronic Disease Death Diastole Echocardiography, Doppler, Pulsed Female Heart Failure / epidemiology, etiology Hospitalization Humans Male Middle Aged Natriuretic Peptide, Brain / blood Predictive Value of Tests Pulmonary Embolism / blood, complications* Ventricular Dysfunction, Right / blood, etiology, ultrasonography* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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