Document Detail

Doppler flow velocimetry of the splenic artery in the human fetus: is it a marker of chronic hypoxia?
MedLine Citation:
PMID:  7892870     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this investigation was to describe splenic artery flow velocity waveforms in the appropriate- and small-for-gestational-age human fetus. STUDY DESIGN: Splenic artery flow velocity waveforms were prospectively obtained from 95 appropriate- and 15 small-for-gestational-age fetuses with pulsed Doppler ultrasonography. The resistance index was used to quantify the Doppler waveform. RESULTS: A second-degree polynomial model expressed the changes of the resistance index in appropriate-for-gestational-age fetuses with advancing gestation (y = 0.057x [Weeks] - 0.001x2, r = 0.53, p < 0.001). In 14 of 15 (93%) small-for-gestational-age fetuses the splenic artery resistance index was below the mean for gestational age. In five of 15 (33%) small-for-gestational-age fetuses the resistance index of the splenic artery was < 2 SEMs. A trend toward a higher hematocrit was noted in the five fetuses with splenic artery resistance index values < 2 SEMs (50.2%) compared with other small-for-gestational-age fetuses (43.0%). CONCLUSION: Our results suggest that some small-for-gestational-age fetuses have decreased resistance at the level of the splenic artery. We postulate that the increased erythropoietin level, stimulated by hypoxia, results in decreased resistance at the level of the splenic artery in small-for-gestational-age fetuses. Finally, management of the small-for-gestational-age fetus may be aided by the study of the splenic artery waveforms.
A Z Abuhamad; G Mari; D Bogdan; A T Evans
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  172     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-04-14     Completed Date:  1995-04-14     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  820-5     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk 23507.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Flow Velocity
Cross-Sectional Studies
Fetal Growth Retardation / physiopathology,  ultrasonography*
Fetal Hypoxia / physiopathology,  ultrasonography*
Splenic Artery / physiopathology,  ultrasonography*
Ultrasonography, Doppler
Vascular Resistance

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Arterial oxygen saturation in relation to metabolic acidosis in fetal lambs.
Next Document:  The effect of lipid peroxides on isolated human umbilical artery contraction.