Document Detail

Doppler echocardiographic evaluation of streptokinase lysis of thrombosed right-sided St. Jude Medical valves in patients with congenital heart defects.
MedLine Citation:
PMID:  2008839     Owner:  NLM     Status:  MEDLINE    
Four episodes of St. Jude Medical prosthesis leaflet thrombosis were serially evaluated by two-dimensional and Doppler echocardiography during treatment with streptokinase. Three patients aged 4, 11, and 24 years with congenital heart disease had St. Jude Medical valves in pulmonary positions (two cases) for tetralogy of Fallot and in the tricuspid position (one case). The duration of thrombosis was not known in any patient. Leaflet immobility and its resolution were demonstrated by echocardiography and were confirmed fluoroscopically. Continuous wave Doppler echocardiography showed abnormal stenotic gradients in thrombosed valves that were reduced after thrombolysis. These studies demonstrate the utility of two-dimensional and Doppler echocardiography in serial evaluation of prosthetic pulmonary and tricuspid valve thrombosis during thrombolysis.
D A Fyfe; A B Taylor; C H Kline; R M Sade; P C Gillette
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  121     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-05-02     Completed Date:  1991-05-02     Revised Date:  2006-02-27    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1156-60     Citation Subset:  AIM; IM    
Division of Pediatric Cardiology, South Carolina Children's Heart Center, Medical University of South Carolina, Charleston 29425.
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MeSH Terms
Child, Preschool
Drug Evaluation
Echocardiography, Doppler*
Heart Valve Diseases / drug therapy*,  ultrasonography
Heart Valve Prosthesis*
Prosthesis Design
Prosthesis Failure
Pulmonary Valve / ultrasonography
Streptokinase / therapeutic use*
Tetralogy of Fallot / complications*,  ultrasonography
Thrombolytic Therapy*
Thrombosis / drug therapy*,  ultrasonography
Time Factors
Tricuspid Valve / ultrasonography
Reg. No./Substance:
EC 3.4.-/Streptokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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