Document Detail

Doppler determined aortic acceleration after dipyridamole in the prediction of coronary artery disease.
MedLine Citation:
PMID:  8522397     Owner:  NLM     Status:  MEDLINE    
Change in the acceleration of aortic blood flow with stress testing is reported to reflect the presence of myocardial ischaemia. We studied its clinical usefulness when compared with dipyridamole thallium scintigraphy in 101 patients, of whom 64 had coronary angiography. Maximum aortic acceleration increased after dipyridamole (P < 0.0001), although no correlation existed between the aortic acceleration and evidence of thallium perfusion abnormalities. For the patients who had angiography, the increase in aortic acceleration was similar for those with no significant coronary stenoses, single vessel or multi-vessel disease. Compared with coronary angiography, Doppler measurement of maximum aortic acceleration had a sensitivity of 92% and a specificity of 37% for the detection of coronary artery disease. When patients with previous myocardial infarction or left ventricular dysfunction were excluded, there was still no relationship between the maximum aortic acceleration and the presence of coronary artery disease. We conclude that changes in the acceleration of aortic blood flow after dipyridamole stressing do not predict the presence or severity of coronary artery disease as measured from perfusion defects at thallium scintigraphy or by coronary angiography. We have observed a wide variability of aortic maximum acceleration in the evaluation of myocardial ischaemia, which we feel introduces serious limitations to its use in routine clinical practice.
S Dubrey; T Y Huehns; S Parker; R F Jewkes; M I Noble
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of cardiology     Volume:  51     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1996-01-25     Completed Date:  1996-01-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  5-14     Citation Subset:  IM    
Department of Academic Medicine, Charing Cross and Westminster Medical School, London, UK.
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MeSH Terms
Aged, 80 and over
Aorta / drug effects*,  ultrasonography*
Blood Flow Velocity / drug effects
Coronary Angiography
Coronary Circulation / drug effects
Coronary Disease / radiography,  radionuclide imaging*,  ultrasonography
Dipyridamole / diagnostic use*,  pharmacology
Echocardiography, Doppler*
Middle Aged
Myocardial Infarction / radionuclide imaging
Myocardial Ischemia / diagnosis,  radiography,  ultrasonography
Sensitivity and Specificity
Thallium Radioisotopes / diagnostic use
Ventricular Dysfunction, Left / radionuclide imaging
Reg. No./Substance:
0/Thallium Radioisotopes; 58-32-2/Dipyridamole

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