| Doppler derived coronary flow reserve during dobutamine stress echocardiography further improves detection of myocardial ischemia. | |
| | |
MedLine Citation:
|
PMID: 15996524 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The coronary flow velocity (CFV) has been used to estimate coronary flow reserve (CFR) during dobutamine stress echocardiography (DSE). However, the relationship of the CFR to myocardial wall thickening (WT) has not been investigated. OBJECTIVES: The aims of this study were: (1) to assess the feasibility of obtaining systolic and diastolic CFV and thus CFR during DSE and (2) to assess the relation between CFR and stress induced WT. METHODS: Distal left anterior descending CFV was recorded by transthoracic Doppler echocardiography during DSE. Systolic and diastolic velocities were measured at rest, low and peak dobutamine doses, simultaneously, WT of distal anteroseptal segment was assessed by 2D-guided M-mode. The CFV and CFR of patients with normal WT defined as thickening of >50% (group 1) at peak stress were compared to that of patients with abnormal WT (group 2). RESULTS: A total of 67 patients, 34 females and 33 males (mean age of 66.5+/-14.5 years) were studied. The feasibility of assessing the CFR was 97% from peak diastolic velocity, 91% from diastolic time velocity integral, 91% from peak systolic velocity, and 90% from systolic time velocity integral. Contrast agent was used in 6 patients (7%) to obtain the CFV. Twenty-five of 67 patients demonstrated abnormal wall thickening. The percentage of WT was 30.9+/-15.7% in group 2 compared to 80.8+/-24.3% in group 1 (p<0.0001). The 25 patients in group 2, who developed abnormal WT, demonstrated significantly lower CFR at low dose, as well as at peak dobutamine dose compared to patients in group 1 (1.55+/-0.5 vs. 2.03+/-0.6, p<0.008). CONCLUSION: CFV and CFR assessments are feasible during DSE with second harmonic imaging in most patients without use of contrast agent. CFR assessment during DSE correlates well with wall thickening and was able to detect ischemia early before development of wall motion abnormality. |
| | |
Authors:
|
Saeed A L Ahmari; Karen Modesto; Jared Bunch; Vicky Stussy; Amy Dichak; James Seward; Patricia Pellikka; Krishnaswamy Chandrasekaran |
Related Documents
:
|
12804724 - Individual prediction of functional recovery after coronary revascularization in patien... 3157304 - The value of echocardiographic regional wall motion abnormalities in detecting coronary... 6318544 - Measurement of left ventricular ejection fraction in pediatric patients using the nucle... 6969984 - Ventricular aneurysm: cross-sectional echocardiographic approach. 3930114 - Peritonitis, dialysate infusion and lung function in continuous ambulatory peritoneal d... 15796254 - Plasma endothelin-1 levels in patients with rheumatic mitral stenosis and a history of ... |
Publication Detail:
|
Type: Journal Article Date: 2005-06-29 |
Journal Detail:
|
Title: European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology Volume: 7 ISSN: 1525-2167 ISO Abbreviation: Eur J Echocardiogr Publication Date: 2006 Mar |
Date Detail:
|
Created Date: 2006-02-21 Completed Date: 2006-07-13 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100890618 Medline TA: Eur J Echocardiogr Country: England |
Other Details:
|
Languages: eng Pagination: 134-40 Citation Subset: IM |
Affiliation:
|
Echocardiography Lab, Cardiology division, Mayo Clinic, 200 First Street SW, Gonda 6-138 NW, Rochester, MN 55905, USA. naman45@hotmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Blood Flow Velocity Cardiotonic Agents / diagnostic use Chi-Square Distribution Contrast Media Coronary Circulation / physiology* Dobutamine / diagnostic use Echocardiography, Stress* Feasibility Studies Female Humans Male Myocardial Ischemia / physiopathology, ultrasonography* Prospective Studies ROC Curve |
| Chemical | |
Reg. No./Substance:
|
0/Cardiotonic Agents; 0/Contrast Media; 34368-04-2/Dobutamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Caught in the act: serial, real time images of a thrombus traversing from the right to left atrium a...
Next Document: Adaptive functioning in children with seizures: impact of maternal anxiety about epilepsy.