| Doppler ultrasound of hepatic and system hemodynamics in patients with alcoholic liver cirrhosis. | |
| | |
MedLine Citation:
|
PMID: 19277866 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: The progression of liver cirrhosis eventually increases cardiac output, while blood pressure and systemic vascular resistance are reduced. A complex behavior of portal hemodynamic to hepatic artery and system circulation has not yet been presented. There is a lack in knowledge about the correlation of local and systemic circulation parameters to the degree of liver failure, with respect to presence of ascites and esophageal varices. PATIENTS AND METHODS: The study sample was 76 patients hospitalized for established alcoholic liver cirrhosis. Patients were divided into groups according to Child-Pugh clinical score; grade A (n = 24), B (n = 18) and C (n = 18). Ascites was found in 28 patients and esophageal varices in 46. Portal vein flow velocity (PVFV), hepatic artery resistance index (HARI), heart and great vessels within mediastinal cavity were assessed with ultrasound devices equipped with spectral Doppler. RESULTS: Significant differences in mean blood pressure, systemic vascular resistance index (SVRI) minute volume, cardiac index and PVFV were found in the group of patients with the most severe stage (C). In regard to presence of ascites statistically significant difference was observed in elevated mean blood pressure and SVRI. Correlation was found between conjugated HARI to blood pressure and to SVRI. CONCLUSIONS: In patients with liver cirrhosis there is an inversely reciprocal relationship of conjugated HARI with PVFV, correlating to disease grade. PVFV in cirrhosis decreases and HARI values were over 0.7. Study demonstrated that combining echocardiography with abdominal Doppler ultrasound served as valuable non-invasive diagnostic insight in liver and systemic circulation among different grade of cirrhosis. |
| | |
Authors:
|
Drazen Zekanovic; Zekanovic Drazen; Neven Ljubicic; Ljubicic Neven; Marko Boban; Boban Marko; Marko Nikolic; Nikolic Marko; Diana Delic-Brkljacic; Delic-Brkljacic Diana; Petar Gacina; Gacina Petar; Ivo Klarin; Klarin Ivo; Jadranko Turcinov; Turcinov Jadranko |
Related Documents
:
|
3001286 - Alpha adrenoceptor subtype mediating sympathetic mobilization of blood from the hepatic... 15733516 - Hyponatremia in liver cirrhosis: pathophysiological principles of management. 10484426 - Pentoxifylline prevents the transition from the hyperdynamic to hypodynamic response du... 7149596 - Changes in portal pressure and hepatic blood flow after dearterialization of tumour-bea... 19956076 - A cornerstone in the history of hypertension: the seventieth anniversary of the discove... 7460226 - Hypertension following arterial baroreceptor denervation in the unanesthetized dog. |
Publication Detail:
|
Type: Comparative Study; Journal Article Date: 2009-03-10 |
Journal Detail:
|
Title: Digestive diseases and sciences Volume: 55 ISSN: 1573-2568 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 2010 Feb |
Date Detail:
|
Created Date: 2010-01-12 Completed Date: 2010-02-18 Revised Date: 2010-03-01 |
Medline Journal Info:
|
Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: United States |
Other Details:
|
Languages: eng Pagination: 458-66 Citation Subset: AIM; IM |
Affiliation:
|
Department of Internal Medicine, County Hospital Zadar, Zadar, Croatia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Blood Flow Velocity / physiology Blood Pressure / physiology* Female Follow-Up Studies Hepatic Artery / physiopathology*, ultrasonography Humans Liver Circulation / physiology* Liver Cirrhosis, Alcoholic / physiopathology*, ultrasonography Male Middle Aged Portal Vein / physiopathology*, ultrasonography Prognosis Severity of Illness Index Ultrasonography, Doppler, Color / methods* Vascular Resistance / physiology* |
| Comments/Corrections | |
Erratum In:
|
Dig Dis Sci. 2009 Jun;54(6):1377 Note: Drazen, Zekanovic [corrected to Zekanovic, Drazen]; Neven, Ljubicic [corrected to Ljubicic, Neven]; Marko, Boban [corrected to Boban, Marko]; Marko, Nikolic [corrected to Nikolic, Marko]; Diana, Delic-Brkljacic [corrected to Delic-Brkljacic, Diana]; Petar, Gacina [corrected to Gacina, Petar]; Ivo, Klarin [corrected to Klarin, Ivo]; Jadranko, Turcinov [corrected to Turcinov, Jadranko] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The influence of culture on anxiety in latino youth: a review.
Next Document: Gastroparesis and gastroparesis-like syndrome: response to therapy and its predictors.