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Doppler-derived myocardial performance index in patients with impaired left ventricular relaxation and preserved systolic function.
MedLine Citation:
PMID:  19486117     Owner:  NLM     Status:  In-Process    
BACKGROUND: The Doppler-derived myocardial performance index (MPI) has been used in the evaluation of left ventricular (LV) function in several diseases. In patients with isolated diastolic dysfunction, the diagnostic utility of this index remains unclear. The aim of this study was to determine the diagnostic utility of MPI in patients with systemic hypertension, impaired LV relaxation, and normal ejection fraction. METHODS: Thirty hypertensive patients with impaired LV relaxation were compared to 30 control subjects. MPI and its components, isovolumetric relaxation time (IRT), isovolumetric contraction time (ICT), and the ejection time (ET), were measured from LV outflow and mitral inflow Doppler velocity profiles. RESULTS: MPI was higher in patients than in control subjects (0.45 +/- 0.13 vs 0.37 +/- 0.07 P < 0.0029). The increase in MPI was due to the prolongation of IRT without significant change of ICT and ET. MPI cutoff value of > or =0.40 identified impaired LV relaxation with a sensitivity of 63% and specificity of 70% while an IRT >94 ms had a sensitivity of 67% and specificity of 80%. Multivariate analysis identified relative wall thickness, mitral early filling wave velocity (E), and systolic myocardial velocity (Sm) as independent predictors of MPI in patients with hypertension. CONCLUSIONS: MPI was increase in patients with hypertension, diastolic dysfunction, and normal ejection fraction but was not superior to IRT to detect impaired LV relaxation.
José Maria G Fernandes; Ivan Romero Rivera; Benício de Oliveira Romão; Maria Alayde Mendonça; Miriam Lira Castro Vasconcelos; Antônio Carlos Carvalho; Orlando Campos; Angelo Amato V De Paola; Valdir A Moisés
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Publication Detail:
Type:  Journal Article     Date:  2009-05-26
Journal Detail:
Title:  Echocardiography (Mount Kisco, N.Y.)     Volume:  26     ISSN:  1540-8175     ISO Abbreviation:  Echocardiography     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-12-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8511187     Medline TA:  Echocardiography     Country:  United States    
Other Details:
Languages:  eng     Pagination:  907-15     Citation Subset:  IM    
Cardiology Division, Federal University of Alagoas, Federal University of Sao Paulo, Sao Paulo, Brazil.
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