| Dopaminergic modulation of exercise hyperpnoea via D2 receptors in mice. | |
| | |
MedLine Citation:
|
PMID: 22041981 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Dopamine is related to behaviour (including arousal, motivation, and motor control of locomotion) and its turnover in the brain is increased during exercise. We examined the hypothesis that dopamine D2 receptors contribute to exercise hyperpnoea via central neural pathways using the D2-like receptor antagonist raclopride. We simultaneously measured ventilation and pulmonary gas exchange for the first time in mice. Mice injected with saline and raclopride (2 mg/kg body weight; i.p.) were compared for respiratory responses to constant-load exercise at 6 m/min. Each mouse was set in an airtight treadmill chamber. In the resting state, raclopride mice had reduced respiratory frequency (Rf) and minute ventilation (MV) decrease compared with saline mice, but PaCO2 and pulmonary gas exchange were not affected, showing that alveolar ventilation was maintained. Hyperoxic gas inhalation maintained MV in saline mice, and hypercapnic ventilatory responses between the two groups were similar. Treadmill exercise produced an abrupt increase in MV to a maximal level within 1 min and declined to a steady-state level in both groups. Raclopride mice had reduced Rf and MV compared with saline mice during steady states, but showed a similar increase in Rf and MV at exercise onset. Minute ventilation at the steady state was controlled along with VO2 increase in both groups, but was lowered in raclopride mice. Thus, D2 receptors participate in resting breathing patterns to raise Rf and exercise hyperpnoea in the steady state probably through behavioural control, and not central motor command, at exercise onset. |
| | |
Authors:
|
Naoto Tsuchiya; Michiko Iwase; Masahiko Izumizaki; Ikuo Homma |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-10-31 |
Journal Detail:
|
Title: Experimental physiology Volume: - ISSN: 1469-445X ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2011-11-1 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9002940 Medline TA: Exp Physiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Showa University. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Kinetics of exercise-induced neural activation; interpretive dilemma of altered cerebral perfusion.
Next Document: Cost-free and sustainable incentive increases healthy eating decisions during elementary school lunc...