| Dopaminergic influence on the ventilatory response to sustained hypoxia in the cat. | |
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MedLine Citation:
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PMID: 7615430 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined the effects of the dopamine blocker haloperidol (H) on the ventilatory response to sustained hypoxia in awake cats. Ventilation (VE) was measured plethysmographically, and end-tidal PO2 (PETO2) and PCO2 were measured by sampling tracheal gas. Measurements were made before, during, and after 30 min of isocapnic hypoxia after pretreatment with 0.1 mg/kg of H and placebo (P). Experimental runs were conducted on separate days with the P day being first. Two levels of hypoxia were employed. Six cats were studied at a PETO2 of approximately 61 Torr, and six cats were studied at a PETO2 of approximately 41 Torr. In all experiments, isocapnia was maintained and end-tidal PCO2 did not differ on the H and P days. With mild hypoxia after P, VE increased to 137% of air breathing control in the first 5 min of hypoxia and then declined to 102% of control at 25 min of hypoxia. Results on the H day were similar. With more severe hypoxia after P, VE increased to 173% of control at 5 min and then declined to 127% of control. With H, VE increased to 172% of control in the first 5 min and then declined to 149% of control at 25 min. After 25 min of more severe hypoxia, both VE and tidal volume were significantly greater with H than with P (P < 0.05). H reduced the ventilatory decline observed with more severe hypoxia but had no effect on the ventilatory decline in milder hypoxia.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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W Long; N R Anthonisen |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 78 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1995 Apr |
Date Detail:
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Created Date: 1995-08-18 Completed Date: 1995-08-18 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1250-5 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Manitoba, Winnipeg, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anoxia / drug therapy*, metabolism, physiopathology Cats Chemoreceptor Cells / drug effects* Dopamine / metabolism* Haloperidol / pharmacology* Injections, Intramuscular Mass Spectrometry Plethysmography Respiration / drug effects*, physiology Respiratory Function Tests |
| Chemical | |
Reg. No./Substance:
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52-86-8/Haloperidol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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