Document Detail

Dopaminergic influence on the ventilatory response to sustained hypoxia in the cat.
MedLine Citation:
PMID:  7615430     Owner:  NLM     Status:  MEDLINE    
We examined the effects of the dopamine blocker haloperidol (H) on the ventilatory response to sustained hypoxia in awake cats. Ventilation (VE) was measured plethysmographically, and end-tidal PO2 (PETO2) and PCO2 were measured by sampling tracheal gas. Measurements were made before, during, and after 30 min of isocapnic hypoxia after pretreatment with 0.1 mg/kg of H and placebo (P). Experimental runs were conducted on separate days with the P day being first. Two levels of hypoxia were employed. Six cats were studied at a PETO2 of approximately 61 Torr, and six cats were studied at a PETO2 of approximately 41 Torr. In all experiments, isocapnia was maintained and end-tidal PCO2 did not differ on the H and P days. With mild hypoxia after P, VE increased to 137% of air breathing control in the first 5 min of hypoxia and then declined to 102% of control at 25 min of hypoxia. Results on the H day were similar. With more severe hypoxia after P, VE increased to 173% of control at 5 min and then declined to 127% of control. With H, VE increased to 172% of control in the first 5 min and then declined to 149% of control at 25 min. After 25 min of more severe hypoxia, both VE and tidal volume were significantly greater with H than with P (P < 0.05). H reduced the ventilatory decline observed with more severe hypoxia but had no effect on the ventilatory decline in milder hypoxia.(ABSTRACT TRUNCATED AT 250 WORDS)
W Long; N R Anthonisen
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  78     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-08-18     Completed Date:  1995-08-18     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1250-5     Citation Subset:  IM    
Department of Medicine, University of Manitoba, Winnipeg, Canada.
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MeSH Terms
Anoxia / drug therapy*,  metabolism,  physiopathology
Chemoreceptor Cells / drug effects*
Dopamine / metabolism*
Haloperidol / pharmacology*
Injections, Intramuscular
Mass Spectrometry
Respiration / drug effects*,  physiology
Respiratory Function Tests
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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