Document Detail


Dopaminergic graft-induced long-term recovery of complex sensorimotor behaviors in a rat model of Parkinson's disease.
MedLine Citation:
PMID:  9674098     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Transplantation of embryonic dopamine neurons has evolved as an alternative neurosurgical treatment strategy for patients with Parkinson's disease and it is therefore of great interest to further optimise this procedure in experimental studies. We have applied a modified microtransplantation approach in unilaterally 6-hydroxydopamine lesioned rats and observed a substantial and long-lasting functional recovery in complex spontaneous behaviors, such as skilled forelimb use and stepping behavior. The results demonstrate that the rat model of Parkinson's disease is a highly useful tool to study mechanisms of neural plasticity and regeneration. The ability of dopaminergic grafts to restore complex sensorimotor behaviors in animals also indicate their great potential for the development of a successful clinical application.
Authors:
G Nikkhah; C Rosenthal; G Falkenstein; M Samii
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Zentralblatt für Neurochirurgie     Volume:  59     ISSN:  0044-4251     ISO Abbreviation:  Zentralbl. Neurochir.     Publication Date:  1998  
Date Detail:
Created Date:  1998-09-17     Completed Date:  1998-09-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0413646     Medline TA:  Zentralbl Neurochir     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  97-103     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, Nordstadt Hospital. GNikkhah@compuserve.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Mapping
Brain Tissue Transplantation / pathology,  physiology*
Dopamine / physiology*
Female
Fetal Tissue Transplantation / pathology,  physiology*
Motor Skills / drug effects,  physiology*
Nerve Regeneration / physiology
Neuronal Plasticity / physiology
Oxidopamine
Parkinson Disease, Secondary / chemically induced,  pathology,  surgery*
Psychomotor Performance / drug effects,  physiology*
Rats
Rats, Sprague-Dawley
Substantia Nigra / drug effects,  pathology,  physiopathology,  surgery*
Ventral Tegmental Area / pathology,  physiopathology,  transplantation*
Chemical
Reg. No./Substance:
1199-18-4/Oxidopamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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