Document Detail

Dopaminergic control of striatal 5-HT level at normobaric condition and at pressure.
MedLine Citation:
PMID:  20568545     Owner:  NLM     Status:  MEDLINE    
High pressure of helium-oxygen (He-O2) increases the extracellular levels in both serotonine and dopamine in the rat striatum. Some motor symptoms evoked by high pressure (i.e., LMA) are known to be reduced by intrastriatal infusions of D1-like (SCH23390, 1 microM) or D2-like (Sulpiride, 1 microM) dopaminergic antagonists. Other studies have also reported that serotoninergic antagonists reduce the motor perturbation at pressure. However, it remains unknown whether the changes in serotoninergic neurotransmission may contribute to the beneficial effects of intrastriatal administration of a dopaminergic antagonist. The present study reports the effects of SCH23390 and sulpiride on serotonin levels in the striatum of rats exposed to 8 MPa of He-O2. Both sulpiride and SCH23390 reduced pressure-induced striatal 5-HT increase. Our data suggest that D1-like and D2-like receptors have similar effects on a pressure-evoked striatal 5-HT increase. Thus, reduction in serotoninergic neurotransmission may be one mechanism by which dopaminergic antagonists reduce motor symptoms at pressure.
O Darbin; J J Risso; J C Rostain
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc     Volume:  37     ISSN:  1066-2936     ISO Abbreviation:  Undersea Hyperb Med     Publication Date:    2010 May-Jun
Date Detail:
Created Date:  2010-06-23     Completed Date:  2010-07-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9312954     Medline TA:  Undersea Hyperb Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  159-66     Citation Subset:  IM; S    
Université de la Méditerranée, Marseille, France.
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MeSH Terms
Atmospheric Pressure*
Benzazepines / pharmacology*
Chromatography, High Pressure Liquid
Corpus Striatum / drug effects*,  metabolism
Dopamine Antagonists / pharmacology*
Hyperbaric Oxygenation
Rats, Sprague-Dawley
Serotonin / metabolism*
Statistics, Nonparametric
Sulpiride / pharmacology*
Reg. No./Substance:
0/Benzazepines; 0/Dopamine Antagonists; 0/SCH 23390; 15676-16-1/Sulpiride; 50-67-9/Serotonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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