Document Detail

Dopaminergic striatal innervation predicts interlimb transfer of a visuomotor skill.
MedLine Citation:
PMID:  21994362     Owner:  NLM     Status:  MEDLINE    
We investigated whether dopamine influences the rate of adaptation to a visuomotor distortion and the transfer of this learning from the right to the left limb in human subjects. We thus studied patients with Parkinson disease as a putative in vivo model of dopaminergic denervation. Despite normal adaptation rates, patients showed a reduced transfer compared with age-matched healthy controls. The magnitude of the transfer, but not of the adaptation rate, was positively predicted by the values of dopamine-transporter binding of the right caudate and putamen. We conclude that striatal dopaminergic activity plays an important role in the transfer of visuomotor skills.
Ioannis U Isaias; Clara Moisello; Giorgio Marotta; Mauro Schiavella; Margherita Canesi; Bernardo Perfetti; Paolo Cavallari; Gianni Pezzoli; M Felice Ghilardi
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  31     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-13     Completed Date:  2011-12-06     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  14458-62     Citation Subset:  IM    
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MeSH Terms
Adaptation, Physiological / physiology*
Brain Mapping
Corpus Striatum / metabolism*,  radionuclide imaging
Dopamine / metabolism*
Dopamine Plasma Membrane Transport Proteins / metabolism
Extremities / physiopathology*
Middle Aged
Motor Skills / physiology*
Parkinson Disease / pathology,  physiopathology
Photic Stimulation / methods
Time Factors
Tomography, Emission-Computed, Single-Photon / methods
Transfer (Psychology) / physiology*
Tropanes / metabolism
Grant Support
NS054864/NS/NINDS NIH HHS; R01 NS054864/NS/NINDS NIH HHS; R01 NS054864-01A1/NS/NINDS NIH HHS; R01 NS054864-02/NS/NINDS NIH HHS; R01 NS054864-03/NS/NINDS NIH HHS; R01 NS054864-04/NS/NINDS NIH HHS; R01 NS054864-05/NS/NINDS NIH HHS
Reg. No./Substance:
0/Dopamine Plasma Membrane Transport Proteins; 0/Tropanes; 155797-99-2/2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane; VTD58H1Z2X/Dopamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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