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Dopaminergic Cell Populations of the Rat Substantia Nigra are Differentially Affected by Essential Fatty Acid Dietary Restriction over Two Generations.
MedLine Citation:
PMID:  22687395     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Essential fatty acids play a crucial role in the activity of several neurotransmission systems, especially in the monoaminergic systems involved in cognitive and motor aspects of behavior. The present study investigated whether essential fatty acid dietary restriction over two generations could differentially affect dopaminergic cell populations located in the substantia nigra rostro-dorso-medial (SNrm) or caudo-ventro-lateral (SNcv) regions which display distinct neurochemical profile and vulnerability to lesions under selected pathological conditions. Wistar rats were raised from conception on control or experimental diets containing adequate or reduced levels of linoleic and α-linolenic fatty acids, respectively. Stereological methods were used to estimate both the number and soma size of tyrosine hydroxylase (TH)-immunoreactive neurons in the SNrm and SNcv. TH protein levels were assessed with Western blots. Long-term treatment with the experimental diet modified the fatty acid profile of midbrain phospholipids and significantly decreased TH protein levels in the ventral midbrain (3 fold), the number of TH-positive cells in the SNrm (∼20%) and the soma size of these neurons in both SNrm (∼20%) and SNcv (∼10%). The results demonstrate for the first time a differential sensitivity of two substantia nigra dopaminergic cell populations to unbalanced levels of essential fatty acids, indicating a higher vulnerability of SNrm to the harmful effects induced by docosahexaenoic acid brain deficiency.
Authors:
Priscila Pereira Passos; Juliana Maria Carrazone Borba; Ana Paula Rocha de Melo; Rubem Carlos Araujo Guedes; Reginaldo Pereira da Silva; Waldenício Teixeira Melo Filho; Kátia Maria Marques Gouveia; Daniela Maria do Amaral Ferraz Navarro; Geanne Karla Novais Santos; Roseane Borner; Cristovam Wanderley Picanço-Diniz; Antonio Jr Pereira; Miriam Stela Maris de Oliveira Costa; Marcelo Cairrão Araújo Rodrigues; Belmira Lara da Silveira Andrade-da-Costa
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-8
Journal Detail:
Title:  Journal of chemical neuroanatomy     Volume:  -     ISSN:  1873-6300     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8902615     Medline TA:  J Chem Neuroanat     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
Affiliation:
Departamento de Fisiologia e Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Pernambuco, Cidade Universitária, Recife (PE), Brazil.
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