| Dopamine versus norepinephrine: is one better? | |
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MedLine Citation:
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PMID: 19412154 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dopamine and norepinephrine are widely used as first line agents to correct hypotension in patients with acute circulatory failure. There has been considerable debate in recent years as to whether one is better than the other. Both drugs can increase blood pressure in shock states, although norepinephrine is more powerful. Dopamine can increase cardiac output more than norepinephrine, and in addition to the increase in global blood flow, has the potential advantage of increasing renal and hepatosplanchnic blood flow. However, dopamine has potentially detrimental effects on the release of pituitary hormones and especially prolactin, although the clinical relevance of these effects is unclear. Observational studies have provided conflicting results regarding the effects of these two drugs on outcomes, and results from a recently completed randomized controlled trial are eagerly waited. |
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Authors:
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J-L Vincent; P Biston; J Devriendt; A Brasseur; D De Backer |
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Publication Detail:
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Type: Comparative Study; Journal Article; Review |
Journal Detail:
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Title: Minerva anestesiologica Volume: 75 ISSN: 1827-1596 ISO Abbreviation: Minerva Anestesiol Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-05-04 Completed Date: 2009-07-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375272 Medline TA: Minerva Anestesiol Country: Italy |
Other Details:
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Languages: eng Pagination: 333-7 Citation Subset: IM |
Affiliation:
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Department of Intensive Care, Erasme Hospital, Brussels, Belgium. jlvincen@ulb.ac.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Agonists
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pharmacology,
therapeutic use Animals Cardiac Output / drug effects Dopamine / pharmacology, therapeutic use* Double-Blind Method Humans Ischemia / prevention & control Kidney / drug effects Liver Circulation / drug effects Norepinephrine / pharmacology, therapeutic use* Pituitary Gland, Anterior / drug effects, secretion Pituitary Hormones / secretion Randomized Controlled Trials as Topic Renal Circulation / drug effects Respiration / drug effects Shock / drug therapy*, physiopathology Shock, Septic / drug therapy, physiopathology Splanchnic Circulation / drug effects Vasomotor System / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Agonists; 0/Pituitary Hormones; 51-41-2/Norepinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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