Document Detail

Dopamine transporter levels in cocaine dependent subjects.
MedLine Citation:
PMID:  18565692     Owner:  NLM     Status:  MEDLINE    
Cocaine use is a significant problem in the US and it is well established that cocaine binds to the dopamine transporter (DAT) in the brain. This study was designed to determine if the DAT levels measured by 99mTc TRODAT SPECT (single photon emission computed tomography) brain scans are altered in cocaine dependent subjects and to explore clinical correlates of such alterations. SPECT brain scans were acquired on 21 cocaine dependent subjects and 21 healthy matched controls. There were significantly higher DAT levels in cocaine dependent subjects compared to controls for the anterior putamen (p=0.003; Cohen's d effect size=0.98), posterior putamen (p<0.001; effect size=1.32), and caudate (p=0.003; effect size=0.97). DAT levels in these regions were 10%, 17%, and 8% higher in the cocaine dependent subjects compared to controls. DAT levels were unrelated to craving, severity of cocaine use, or duration of cocaine use, but DAT levels in the caudate and anterior putamen were significantly (p<0.05) negatively correlated with days since last use of cocaine.
Paul Crits-Christoph; Andrew Newberg; Nancy Wintering; Karl Ploessl; Mary Beth Connolly Gibbons; Sarah Ring-Kurtz; Robert Gallop; Julie Present
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-06-20
Journal Detail:
Title:  Drug and alcohol dependence     Volume:  98     ISSN:  0376-8716     ISO Abbreviation:  Drug Alcohol Depend     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-09-03     Completed Date:  2009-01-23     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  7513587     Medline TA:  Drug Alcohol Depend     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  70-6     Citation Subset:  IM    
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MeSH Terms
Basal Ganglia / drug effects,  radionuclide imaging*
Caudate Nucleus / drug effects,  radionuclide imaging
Cocaine-Related Disorders / radionuclide imaging*
Dominance, Cerebral / physiology
Dopamine Plasma Membrane Transport Proteins / drug effects,  metabolism*
Middle Aged
Organotechnetium Compounds / diagnostic use
Putamen / drug effects,  radionuclide imaging
Reference Values
Tomography, Emission-Computed, Single-Photon*
Tropanes / diagnostic use
Grant Support
R01 AG-17524/AG/NIA NIH HHS; R21 DA-016002/DA/NIDA NIH HHS; R21 DA016002/DA/NIDA NIH HHS; R21 DA016002-01/DA/NIDA NIH HHS; R21 DA016002-02/DA/NIDA NIH HHS; R21 DA016002-03/DA/NIDA NIH HHS
Reg. No./Substance:
0/Dopamine Plasma Membrane Transport Proteins; 0/Organotechnetium Compounds; 0/Tropanes; 0/technetium Tc 99m TRODAT-1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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