| Dopamine suppresses octopamine signaling in C. elegans: possible involvement of dopamine in the regulation of lifespan. | |
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MedLine Citation:
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PMID: 20157560 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Amine neurotransmitters, such as dopamine, serotonin, and noradrenaline, play important roles in the modulation of behaviors and metabolism of animals. InC. elegans, it has been shown that serotonin and octopamine, an invertebrate equivalent of noradrenaline, also regulate lifespan through a mechanism related to food deprivation-mediated lifespan extension. We have shown recently that dopamine signaling, activated by the tactile perception of food, suppresses octopamine signaling and that the cessation of dopamine signaling in the absence of food leads to activation of octopamine signaling. Here, we discuss the apparent conservation of neural and molecular mechanisms for dopamine regulation of octopamine/noradrenaline signaling and a possible role for dopamine in lifespan regulation. |
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Authors:
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Satoshi Suo; Joseph G Culotti; Hubert H M Van Tol |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-10-21 |
Journal Detail:
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Title: Aging Volume: 1 ISSN: 1945-4589 ISO Abbreviation: Aging (Albany NY) Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2010-02-16 Completed Date: 2010-06-16 Revised Date: 2010-09-28 |
Medline Journal Info:
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Nlm Unique ID: 101508617 Medline TA: Aging (Albany NY) Country: United States |
Other Details:
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Languages: eng Pagination: 870-4 Citation Subset: IM |
Affiliation:
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Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada, M5G 1X5. satoshi.suo@utoronoto.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology Animals CREB-Binding Protein / physiology Caenorhabditis elegans / physiology* Dopamine / physiology* Food Deprivation / physiology Longevity / physiology* Norepinephrine / physiology Octopamine / physiology* Signal Transduction / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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MOP-77722//Canadian Institutes of Health Research; MOP-82909//Canadian Institutes of Health Research |
| Chemical | |
Reg. No./Substance:
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104-14-3/Octopamine; 51-41-2/Norepinephrine; EC 2.3.1.48/CREB-Binding Protein |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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