Document Detail

Dopamine suppresses octopamine signaling in C. elegans: possible involvement of dopamine in the regulation of lifespan.
MedLine Citation:
PMID:  20157560     Owner:  NLM     Status:  MEDLINE    
Amine neurotransmitters, such as dopamine, serotonin, and noradrenaline, play important roles in the modulation of behaviors and metabolism of animals. InC. elegans, it has been shown that serotonin and octopamine, an invertebrate equivalent of noradrenaline, also regulate lifespan through a mechanism related to food deprivation-mediated lifespan extension. We have shown recently that dopamine signaling, activated by the tactile perception of food, suppresses octopamine signaling and that the cessation of dopamine signaling in the absence of food leads to activation of octopamine signaling. Here, we discuss the apparent conservation of neural and molecular mechanisms for dopamine regulation of octopamine/noradrenaline signaling and a possible role for dopamine in lifespan regulation.
Satoshi Suo; Joseph G Culotti; Hubert H M Van Tol
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-10-21
Journal Detail:
Title:  Aging     Volume:  1     ISSN:  1945-4589     ISO Abbreviation:  Aging (Albany NY)     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2010-02-16     Completed Date:  2010-06-16     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101508617     Medline TA:  Aging (Albany NY)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  870-4     Citation Subset:  IM    
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada, M5G 1X5.
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MeSH Terms
Aging / physiology
CREB-Binding Protein / physiology
Caenorhabditis elegans / physiology*
Dopamine / physiology*
Food Deprivation / physiology
Longevity / physiology*
Norepinephrine / physiology
Octopamine / physiology*
Signal Transduction / physiology*
Grant Support
MOP-77722//Canadian Institutes of Health Research; MOP-82909//Canadian Institutes of Health Research
Reg. No./Substance:
104-14-3/Octopamine; 51-41-2/Norepinephrine; EC Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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