Document Detail


Dopamine and sexual behavior in the male rabbit.
MedLine Citation:
PMID:  8951967     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Male rabbits were treated with the dopamine releasing drug amphetamine or the dopamine D1/D2 receptor antagonist cis(Z)-flupenthixol. Amphetamine, 1 to 4 mg/kg, had no effect on sexual behavior. Flupenthixol, 2 mg/kg, reduced the proportion of rabbits that ejaculated and the number of ejaculations per test. Lower doses were ineffective. Castrated males were treated with both drugs at two intervals after castration, 19-21 and 27-29 days postcastration, respectively. Amphetamine was without effect while flupenthixol, 1 mg/kg, reduced sexual behavior at the test 19-21 days postcastration. At the second test, sexual behavior was almost completely absent in control animals. Therefore, no further reduction could be observed after treatment with flupenthixol. Another group of animals was castrated and given androgen replacement. Testosterone decanoate was injected once weekly at a dose of 3 mg/kg. This treatment maintained a stable, low sexual activity. In these animals, amphetamine was again ineffective whereas flupenthixol, 1 mg/kg, inhibited sexual behavior. Gross motor function was evaluated in a water escape test. Amphetamine was inactive, and the effective dose of flupenthixol was 10 mg/kg. This dose is far above the dose required for inhibiting sexual behavior. In sum, facilitated dopaminergic transmission does not seem to affect on sexual behavior in the male rabbit, whereas reduced dopaminergic activity disrupts this behavior.
Authors:
A Agmo; R G Paredes; J I Ramos; J L Contreras
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  55     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1997-03-13     Completed Date:  1997-03-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  289-95     Citation Subset:  IM    
Affiliation:
Laboratoire de Psychophysiologie, Faculté des Sciences, Université de Tours, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dextroamphetamine / pharmacology
Dopamine / physiology*
Dopamine Antagonists / pharmacology
Dopamine Uptake Inhibitors / pharmacology
Dose-Response Relationship, Drug
Ejaculation / drug effects
Flupenthixol / pharmacology
Male
Maze Learning / drug effects
Orchiectomy
Rabbits
Sexual Behavior, Animal / drug effects,  physiology*
Swimming
Testosterone / pharmacology
Chemical
Reg. No./Substance:
0/Dopamine Antagonists; 0/Dopamine Uptake Inhibitors; 2709-56-0/Flupenthixol; 51-64-9/Dextroamphetamine; 58-22-0/Testosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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