Document Detail


Dopamine and serotonin turnover rate in the retina of rabbit, rat, goldfish, and Eugerres plumieri: light effects in goldfish and rat.
MedLine Citation:
PMID:  7534358     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The concentration of dopamine, and its metabolites 3,4-dihydroxyphenylacetic and homovanillic acids, as well as serotonin and its metabolite 5-hydroxyindoleacetic acid, were determined in the retina of two teleosts, C. auratus (goldfish) and E. plumieri (mojarra), and two mammals, R. norvegicus (rat) and O. cuniculus (rabbit). The turnover rate of these monoamines were investigated in the four species by the calculation of the ratio monoamine/metabolite as an indirect index, and in goldfish and rat by the inhibition of the synthesis with alpha-methyl-p-tyrosine or p-chlorophenylalanine, by the increase in dopamine or serotonin by the corresponding precursors, 3,4-dihydroxyphenylalanine or 5-hydroxytryptophan, and by inhibition of monoaminooxidase with pargyline. The modulation by light and dark stimulation was studied in the goldfish and the rat. Differences in the concentration and turnover rate were observed among the species. Serotonin concentration was higher in the teleosts. The administration of inhibitors of dopamine and serotonin synthesis differentially decreased the levels of the monoamines in the retina of goldfish and rat. The rate of formation of dopamine and serotonin by the corresponding precursors was much higher in the goldfish than in the rat. Pargyline administration decreased 3,4-dihydroxyphenylacetic and 5-hydroxyindoleacetic acids at different rates and time dependency in the retina of goldfish and rat. Dopamine and serotonin concentration did not exhibit high modifications by the inhibitor, suggesting the function of regulatory mechanisms or additional effect of pargyline at other sites different from monoaminooxidase.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
L Lima; M Urbina
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neuroscience research     Volume:  39     ISSN:  0360-4012     ISO Abbreviation:  J. Neurosci. Res.     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-04-19     Completed Date:  1995-04-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600111     Medline TA:  J Neurosci Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  595-603     Citation Subset:  IM    
Affiliation:
Laboratorio de Neuroquímica, Instituto Venezolano de Investigaciones Científicas, Caracas, Venezuela.
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MeSH Terms
Descriptor/Qualifier:
3,4-Dihydroxyphenylacetic Acid / metabolism
5-Hydroxytryptophan / pharmacology
Animals
Carbidopa / pharmacology
Dopamine / metabolism*
Fenclonine / pharmacology
Goldfish / metabolism*
Homovanillic Acid / metabolism
Hydroxyindoleacetic Acid / metabolism
Levodopa / pharmacology
Light*
Male
Methyltyrosines / pharmacology
Pargyline / pharmacology
Perciformes / metabolism*
Rabbits / metabolism*
Rats / metabolism*
Rats, Sprague-Dawley
Retina / metabolism*,  radiation effects
Serotonin / metabolism*
Species Specificity
alpha-Methyltyrosine
Chemical
Reg. No./Substance:
0/Levodopa; 0/Methyltyrosines; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 306-08-1/Homovanillic Acid; 38821-49-7/Carbidopa; 50-67-9/Serotonin; 54-16-0/Hydroxyindoleacetic Acid; 555-57-7/Pargyline; 56-69-9/5-Hydroxytryptophan; 658-48-0/alpha-Methyltyrosine; 7424-00-2/Fenclonine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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