| Dopamine and serotonin transporters in patients with schizophrenia: an imaging study with [(123)I]beta-CIT. | |
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MedLine Citation:
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PMID: 10704949 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Several lines of evidence derived from imaging and postmortem studies suggest that schizophrenia is associated with hyperactivity of dopamine function and deficiency in serotonin (5-HT) function. The aim of this study was to investigate potential alterations of striatal dopamine transporters (DAT) and brainstem serotonin transporters (SERT) density in schizophrenia. METHODS: Striatal DAT and brainstem SERT were measured in 24 patients with schizophrenia and 22 matched healthy control subjects using single photon emission computed tomography and [(123)I]beta-CIT. In this cohort of subjects, we previously reported an increase in striatal amphetamine-induced dopamine release, measured as the displacement of the D(2) receptor radiotracer [(123)I]IBZM. RESULTS: No differences were observed between patients and control subjects in the equilibrium uptake ratio (V(3)") of [(123)I]beta-CIT in the striatum, indicating that schizophrenia is not generally associated with an alteration of striatal DAT density; however, a trend level association (p =.07) was observed in patients with schizophrenia between low striatal [(123)I]beta-CIT V(3)" and severity of negative symptoms. After controlling for age, striatal [(123)I]beta-CIT V(3)" in patients was not associated with duration of illness, suggesting that this relative deficit was not secondary to a neurodegenerative process. No correlation was observed between DAT density and amphetamine-induced dopamine release, either in the patients or in the controls. Brainstem [(123)I]beta-CIT V(3)" was unaffected in patients with schizophrenia, and was unrelated to symptomatology. CONCLUSIONS: Schizophrenia is generally not associated with alterations of DAT in the striatum or SERT in the brainstem. In some patients, a relative deficit in dopamine nerve terminals might play a role in the pathophysiology of negative symptoms. |
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Authors:
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M Laruelle; A Abi-Dargham; C van Dyck; R Gil; D C D'Souza; J Krystal; J Seibyl; R Baldwin; R Innis |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biological psychiatry Volume: 47 ISSN: 0006-3223 ISO Abbreviation: Biol. Psychiatry Publication Date: 2000 Mar |
Date Detail:
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Created Date: 2000-03-28 Completed Date: 2000-03-28 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0213264 Medline TA: Biol Psychiatry Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 371-9 Citation Subset: IM |
Affiliation:
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New York State Psychiatric Institute, Columbia University College of Physicians and Surgeons, New York 10032, USA. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Brain Stem / metabolism*, radionuclide imaging Carrier Proteins / metabolism* Case-Control Studies Cocaine / analogs & derivatives*, diagnostic use Dopamine / metabolism Dopamine Plasma Membrane Transport Proteins Female Humans Iodine Radioisotopes / diagnostic use* Male Membrane Glycoproteins / metabolism* Membrane Transport Proteins* Middle Aged Neostriatum / metabolism*, radionuclide imaging Nerve Tissue Proteins / metabolism* Schizophrenia / metabolism*, radionuclide imaging* Serotonin / metabolism Serotonin Plasma Membrane Transport Proteins Tomography, Emission-Computed, Single-Photon* / methods |
| Grant Support | |
ID/Acronym/Agency:
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KO2MH01603/MH/NIMH NIH HHS; MH30929/MH/NIMH NIH HHS; R01MH54192/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Carrier Proteins; 0/Dopamine Plasma Membrane Transport Proteins; 0/Iodine Radioisotopes; 0/Membrane Glycoproteins; 0/Membrane Transport Proteins; 0/Nerve Tissue Proteins; 0/SLC6A3 protein, human; 0/SLC6A4 protein, human; 0/Serotonin Plasma Membrane Transport Proteins; 133647-95-7/RTI 55; 50-36-2/Cocaine; 50-67-9/Serotonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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